Matches in SemOpenAlex for { <https://semopenalex.org/work/W1532158051> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W1532158051 endingPage "1855" @default.
- W1532158051 startingPage "1855" @default.
- W1532158051 abstract "Nitric oxide (NO), produced by NO synthase (NOS), modulates the function of all retinal neurons and ocular blood vessels and participates in the pathogenesis of ocular diseases. To further understand the regulation of ocular NO release, we systematically studied the morphology, topography, and light responses of NOS-containing amacrine cells (NOACs) in dark-adapted mouse retina. Immunohistological staining for neuronal NOS (bNOS), combined with retrograde labeling of ganglion cells (GCs) with Neurobiotin (NB, a gap junction permeable dye) and Lucifer yellow (LY, a less permeable dye), was used to identify NOACs. The light responses of ACs were recorded under whole-cell voltage clamp conditions and cell morphology was examined with a confocal microscope. We found that in dark-adapted conditions bNOS-immunoreactivity (IR) was present primarily in the inner nuclear layer and the ganglion cell layer. bNOS-IR somas were negative for LY, thus they were identified as ACs; nearly 6% of the cells were labeled by NB but not by LY, indicating that they were dye-coupled with GCs. Three morphological subtypes of NOACs (NI, NII, and displaced) were identified. The cell density, intercellular distance, and the distribution of NOACs were studied in whole retinas. Light evoked depolarizing highly sensitive ON-OFF responses in NI cells and less sensitive OFF responses in NII cells. Frequent (1–2 Hz) or abrupt change of light intensity evoked larger peak responses. The possibility for light to modify NO release from NOACs is discussed. J. Comp. Neurol. 518:2456–2474, 2010." @default.
- W1532158051 created "2016-06-24" @default.
- W1532158051 creator A5039439562 @default.
- W1532158051 creator A5047296464 @default.
- W1532158051 creator A5053967420 @default.
- W1532158051 date "2010-04-17" @default.
- W1532158051 modified "2023-09-24" @default.
- W1532158051 title "Light Responses and Morphology of bNOS-Immunoreactive Neurons in the Mouse Retina" @default.
- W1532158051 hasPublicationYear "2010" @default.
- W1532158051 type Work @default.
- W1532158051 sameAs 1532158051 @default.
- W1532158051 citedByCount "0" @default.
- W1532158051 crossrefType "journal-article" @default.
- W1532158051 hasAuthorship W1532158051A5039439562 @default.
- W1532158051 hasAuthorship W1532158051A5047296464 @default.
- W1532158051 hasAuthorship W1532158051A5053967420 @default.
- W1532158051 hasConcept C105702510 @default.
- W1532158051 hasConcept C12554922 @default.
- W1532158051 hasConcept C153911025 @default.
- W1532158051 hasConcept C158157758 @default.
- W1532158051 hasConcept C169760540 @default.
- W1532158051 hasConcept C185592680 @default.
- W1532158051 hasConcept C2777093970 @default.
- W1532158051 hasConcept C2777506830 @default.
- W1532158051 hasConcept C2779486281 @default.
- W1532158051 hasConcept C2780188069 @default.
- W1532158051 hasConcept C4141045 @default.
- W1532158051 hasConcept C79879829 @default.
- W1532158051 hasConcept C86803240 @default.
- W1532158051 hasConcept C95444343 @default.
- W1532158051 hasConceptScore W1532158051C105702510 @default.
- W1532158051 hasConceptScore W1532158051C12554922 @default.
- W1532158051 hasConceptScore W1532158051C153911025 @default.
- W1532158051 hasConceptScore W1532158051C158157758 @default.
- W1532158051 hasConceptScore W1532158051C169760540 @default.
- W1532158051 hasConceptScore W1532158051C185592680 @default.
- W1532158051 hasConceptScore W1532158051C2777093970 @default.
- W1532158051 hasConceptScore W1532158051C2777506830 @default.
- W1532158051 hasConceptScore W1532158051C2779486281 @default.
- W1532158051 hasConceptScore W1532158051C2780188069 @default.
- W1532158051 hasConceptScore W1532158051C4141045 @default.
- W1532158051 hasConceptScore W1532158051C79879829 @default.
- W1532158051 hasConceptScore W1532158051C86803240 @default.
- W1532158051 hasConceptScore W1532158051C95444343 @default.
- W1532158051 hasIssue "13" @default.
- W1532158051 hasLocation W15321580511 @default.
- W1532158051 hasOpenAccess W1532158051 @default.
- W1532158051 hasPrimaryLocation W15321580511 @default.
- W1532158051 hasRelatedWork W1621225779 @default.
- W1532158051 hasRelatedWork W1976834708 @default.
- W1532158051 hasRelatedWork W1977244277 @default.
- W1532158051 hasRelatedWork W1997085902 @default.
- W1532158051 hasRelatedWork W1999982526 @default.
- W1532158051 hasRelatedWork W2010581941 @default.
- W1532158051 hasRelatedWork W2011830669 @default.
- W1532158051 hasRelatedWork W2016658997 @default.
- W1532158051 hasRelatedWork W2031294500 @default.
- W1532158051 hasRelatedWork W2039476432 @default.
- W1532158051 hasRelatedWork W2051765304 @default.
- W1532158051 hasRelatedWork W2069378170 @default.
- W1532158051 hasRelatedWork W2080236688 @default.
- W1532158051 hasRelatedWork W2094183914 @default.
- W1532158051 hasRelatedWork W2146357050 @default.
- W1532158051 hasRelatedWork W2171186350 @default.
- W1532158051 hasRelatedWork W2391262806 @default.
- W1532158051 hasRelatedWork W2399764452 @default.
- W1532158051 hasRelatedWork W2419918257 @default.
- W1532158051 hasRelatedWork W9253864 @default.
- W1532158051 hasVolume "51" @default.
- W1532158051 isParatext "false" @default.
- W1532158051 isRetracted "false" @default.
- W1532158051 magId "1532158051" @default.
- W1532158051 workType "article" @default.