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• W153219478 endingPage "640" @default.
• W153219478 startingPage "629" @default.
• W153219478 abstract "Biochemical hypotheses of affective disorders have been largely derived from animal studies involving the acute administration of antidepressant drugs. However, the fact that in clinical use these drugs require approximately 2 weeks to elicit a therapeutic response, coupled with current concepts of control processes in central monoaminergic neurons led us to examine the effects of a chronic phenelzine regime on 5-hydroxytryptaminergic and noradrenergic neurones in the rat brain. Dose and time schedules were determined after single dose studies. Phenalzine was given as 15 mg/kg/48 hr for 7, 14 and 21 days. In all cases, animals wore sacrificed 6 hours after the last dose of drug. The uptake of tryptophan, tyrosine, 5-hydroxytryptamine and norepinephrine into cortical synaptosomes was examined at weekly intervals during the phenelzine regime. Following a single dose, the only significant finding is an increase in the uptake of tryptophan and after 7 and 14 days, increased uptake of tyrosine is the only significant change. After 21 days, there is significant decrease in norepinephrine uptake. During the phenelzine regime monoamine oxidase activity in brain (using tyramine as substrate) decreases linearly from 50 to 5% of controls (from 1 to 21 days). Endogenous levels of norepinephrine and 5-hydroxytryptamine show an increase after one injection of phenelzine but over 21 days there is an adaptive response and amine values return towards control levels. While tyrosine hydroxylase is unchanged by the phenelzine regime, tryptophan hydroxylase is significantly raised in the drug-treated groups." @default.
• W153219478 created "2016-06-24" @default.
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• W153219478 date "1978-01-01" @default.
• W153219478 modified "2023-09-27" @default.
• W153219478 title "NOREPINEPHRINE AND SEROTONIN METABOLISM IN THE RAT BRAIN: EFFECTS OF CHRONIC PHENELZINE ADMINISTRATION" @default.
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• W153219478 doi "https://doi.org/10.1016/b978-1-4832-8322-7.50093-5" @default.
• W153219478 hasPublicationYear "1978" @default.
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