FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1532206496> ?p ?o ?g. }

• W1532206496 endingPage "2240" @default.
• W1532206496 startingPage "2229" @default.
• W1532206496 abstract "Abstract IL-19, IL-20, IL-22, IL-24, and IL-26 are members of the IL-10 family of cytokines that have been shown to be up-regulated in psoriatic skin. Contrary to IL-10, these cytokines signal using receptor complex R1 subunits that are preferentially expressed on cells of epithelial origin; thus, we henceforth refer to them as the IL-20 subfamily cytokines. In this study, we show that primary human keratinocytes (KCs) express receptors for these cytokines and that IL-19, IL-20, IL-22, and IL-24 induce acanthosis in reconstituted human epidermis (RHE) in a dose-dependent manner. These cytokines also induce expression of the psoriasis-associated protein S100A7 and keratin 16 in RHE and cause persistent activation of Stat3 with nuclear localization. IL-22 had the most pronounced effects on KC proliferation and on the differentiation of KCs in RHE, inducing a decrease in the granular cell layer (hypogranulosis). Furthermore, gene expression analysis performed on cultured RHE treated with these cytokines showed that IL-19, IL-20, IL-22, and IL-24 regulate many of these same genes to variable degrees, inducing a gene expression profile consistent with inflammatory responses, wound healing re-epithelialization, and altered differentiation. Many of these genes have also been found to be up-regulated in psoriatic skin, including several chemokines, β-defensins, S100 family proteins, and kallikreins. These results confirm that IL-20 subfamily cytokines are important regulators of epidermal KC biology with potentially pivotal roles in the immunopathology of psoriasis." @default.
• W1532206496 created "2016-06-24" @default.
• W1532206496 creator A5002337965 @default.
• W1532206496 creator A5005063159 @default.
• W1532206496 creator A5005121699 @default.
• W1532206496 creator A5011313053 @default.
• W1532206496 creator A5013851971 @default.
• W1532206496 creator A5018281554 @default.
• W1532206496 creator A5037917105 @default.
• W1532206496 creator A5048506216 @default.
• W1532206496 creator A5053997664 @default.
• W1532206496 creator A5074916693 @default.
• W1532206496 creator A5079320356 @default.
• W1532206496 date "2007-02-15" @default.
• W1532206496 modified "2023-10-05" @default.
• W1532206496 title "The Effects of IL-20 Subfamily Cytokines on Reconstituted Human Epidermis Suggest Potential Roles in Cutaneous Innate Defense and Pathogenic Adaptive Immunity in Psoriasis" @default.
• W1532206496 cites W1490343462 @default.
• W1532206496 cites W151366572 @default.
• W1532206496 cites W1526574246 @default.
• W1532206496 cites W1576903429 @default.
• W1532206496 cites W1788079032 @default.
• W1532206496 cites W182986896 @default.
• W1532206496 cites W1964895626 @default.
• W1532206496 cites W1973326314 @default.
• W1532206496 cites W1976586538 @default.
• W1532206496 cites W1977781495 @default.
• W1532206496 cites W1977911881 @default.
• W1532206496 cites W1979022543 @default.
• W1532206496 cites W1979962636 @default.
• W1532206496 cites W1981799488 @default.
• W1532206496 cites W1986120120 @default.
• W1532206496 cites W1986393742 @default.
• W1532206496 cites W1987287925 @default.
• W1532206496 cites W1987389251 @default.
• W1532206496 cites W1988177114 @default.
• W1532206496 cites W1994678939 @default.
• W1532206496 cites W1997360117 @default.
• W1532206496 cites W2000076767 @default.
• W1532206496 cites W2005359518 @default.
• W1532206496 cites W2005581733 @default.
• W1532206496 cites W2006120701 @default.
• W1532206496 cites W2007121925 @default.
• W1532206496 cites W2013488106 @default.
• W1532206496 cites W2015757416 @default.
• W1532206496 cites W2015823644 @default.
• W1532206496 cites W2019160498 @default.
• W1532206496 cites W2038131331 @default.
• W1532206496 cites W2049702967 @default.
• W1532206496 cites W2053671225 @default.
• W1532206496 cites W2057985881 @default.
• W1532206496 cites W2059196563 @default.
• W1532206496 cites W2059966251 @default.
• W1532206496 cites W2067520762 @default.
• W1532206496 cites W2068281838 @default.
• W1532206496 cites W2072794124 @default.
• W1532206496 cites W2074360288 @default.
• W1532206496 cites W2079057075 @default.
• W1532206496 cites W2079474508 @default.
• W1532206496 cites W2079556349 @default.
• W1532206496 cites W2083802827 @default.
• W1532206496 cites W2091347085 @default.
• W1532206496 cites W2093949724 @default.
• W1532206496 cites W2103533676 @default.
• W1532206496 cites W2104152486 @default.
• W1532206496 cites W2104201959 @default.
• W1532206496 cites W2109453886 @default.
• W1532206496 cites W2117288212 @default.
• W1532206496 cites W2124846094 @default.
• W1532206496 cites W2128229361 @default.
• W1532206496 cites W2129632766 @default.
• W1532206496 cites W2133657961 @default.
• W1532206496 cites W2135615816 @default.
• W1532206496 cites W2138061716 @default.
• W1532206496 cites W2141077451 @default.
• W1532206496 cites W2143076511 @default.
• W1532206496 cites W2143307899 @default.
• W1532206496 cites W2143364414 @default.
• W1532206496 cites W2146400618 @default.
• W1532206496 cites W2152397966 @default.
• W1532206496 cites W2157713142 @default.
• W1532206496 cites W2159975620 @default.
• W1532206496 cites W2325059160 @default.
• W1532206496 cites W2325727928 @default.
• W1532206496 cites W2415155044 @default.
• W1532206496 cites W4233524499 @default.
• W1532206496 cites W4236396577 @default.
• W1532206496 cites W4246066740 @default.
• W1532206496 doi "https://doi.org/10.4049/jimmunol.178.4.2229" @default.
• W1532206496 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17277128" @default.
• W1532206496 hasPublicationYear "2007" @default.
• W1532206496 type Work @default.
• W1532206496 sameAs 1532206496 @default.
• W1532206496 citedByCount "439" @default.
• W1532206496 countsByYear W15322064962012 @default.
• W1532206496 countsByYear W15322064962013 @default.
• W1532206496 countsByYear W15322064962014 @default.
• W1532206496 countsByYear W15322064962015 @default.
• W1532206496 countsByYear W15322064962016 @default.

• next