FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1532242553> ?p ?o ?g. }

• W1532242553 endingPage "220" @default.
• W1532242553 startingPage "201" @default.
• W1532242553 abstract "The mechanism by which cells respond to extracellular stimuli involves a series of signal transduction events across the cell membrane and through the cytoplasm to the nucleus. Mitogen-activated protein (MAP) kinases are important mediators of signal transduction and play a key role in the regulation of many cellular processes, such as cell growth and proliferation, differentiation, and apoptosis. In mammalian cells, three major groups of MAP kinases have been identified: extracellular signal-regulated kinase (ERK), c-jun N-terminal kinase (JNK), and p38 MAP kinase. It is well documented that ERK is typically stimulated by growth-related signals, whereas the JNK and p38 MAP kinase cascades are activated by various stress stimuli. Studies have indicated that MAP kinases are expressed abundantly in the central nervous system (CNS) and that ERK is involved in long-lasting neuronal plasticity, including long-term potentiation and memory consolidation. While the role of ERK in neuronal plasticity and behavioral adaptation is beginning to emerge, the role of MAP kinase signal transduction cascades in major psychiatric disorders, including schizophrenia, is not well understood. This review outlines the intermediates of this signaling cascade and downstream transcription factor targets and recent evidence implicating MAP kinases to important biological functions in the CNS. Evidence from human post-mortem studies, as well as from the phencyclidine model of schizophrenia, that different MAP kinase cascades may be involved in the pathogenesis of schizophrenia, and potentially in other psychiatric disorders, is presented. Knowledge of MAP kinase signaling will aid greatly in our ability t o understand causal changes in disease process and may lead to new therapeutic approaches in controlling or treating schizophrenia." @default.
• W1532242553 created "2016-06-24" @default.
• W1532242553 creator A5026018766 @default.
• W1532242553 date "2004-01-01" @default.
• W1532242553 modified "2023-09-25" @default.
• W1532242553 title "Mitogen-Activated Protein Kinase Signaling" @default.
• W1532242553 cites W14552048 @default.
• W1532242553 cites W1485925377 @default.
• W1532242553 cites W1486190676 @default.
• W1532242553 cites W1489512833 @default.
• W1532242553 cites W1499601028 @default.
• W1532242553 cites W1565099167 @default.
• W1532242553 cites W1566737177 @default.
• W1532242553 cites W1584917605 @default.
• W1532242553 cites W1586693095 @default.
• W1532242553 cites W1588192538 @default.
• W1532242553 cites W1596996692 @default.
• W1532242553 cites W1597498191 @default.
• W1532242553 cites W1597741096 @default.
• W1532242553 cites W1597741258 @default.
• W1532242553 cites W1606506184 @default.
• W1532242553 cites W1639247045 @default.
• W1532242553 cites W1710423957 @default.
• W1532242553 cites W1738144688 @default.
• W1532242553 cites W1783361713 @default.
• W1532242553 cites W1796948519 @default.
• W1532242553 cites W1798150371 @default.
• W1532242553 cites W1801032533 @default.
• W1532242553 cites W181622860 @default.
• W1532242553 cites W1857242751 @default.
• W1532242553 cites W1864334043 @default.
• W1532242553 cites W1899552864 @default.
• W1532242553 cites W1903998424 @default.
• W1532242553 cites W1906221324 @default.
• W1532242553 cites W1923773257 @default.
• W1532242553 cites W1937172266 @default.
• W1532242553 cites W1938343654 @default.
• W1532242553 cites W1961049630 @default.
• W1532242553 cites W1964486755 @default.
• W1532242553 cites W1964785626 @default.
• W1532242553 cites W1966988598 @default.
• W1532242553 cites W1967746478 @default.
• W1532242553 cites W1969920081 @default.
• W1532242553 cites W1973513869 @default.
• W1532242553 cites W1973614704 @default.
• W1532242553 cites W1974145667 @default.
• W1532242553 cites W1975141304 @default.
• W1532242553 cites W1976310806 @default.
• W1532242553 cites W1976385326 @default.
• W1532242553 cites W1976441097 @default.
• W1532242553 cites W1976569303 @default.
• W1532242553 cites W1977472414 @default.
• W1532242553 cites W1978888709 @default.
• W1532242553 cites W1979067225 @default.
• W1532242553 cites W1979215811 @default.
• W1532242553 cites W1979284770 @default.
• W1532242553 cites W1979697286 @default.
• W1532242553 cites W1981883990 @default.
• W1532242553 cites W1982245162 @default.
• W1532242553 cites W1984903682 @default.
• W1532242553 cites W1988004907 @default.
• W1532242553 cites W1989849863 @default.
• W1532242553 cites W1990476575 @default.
• W1532242553 cites W1991503782 @default.
• W1532242553 cites W1991573200 @default.
• W1532242553 cites W1991659817 @default.
• W1532242553 cites W1993191556 @default.
• W1532242553 cites W1994219871 @default.
• W1532242553 cites W1996376088 @default.
• W1532242553 cites W1996401008 @default.
• W1532242553 cites W1999605572 @default.
• W1532242553 cites W1999782689 @default.
• W1532242553 cites W2000476522 @default.
• W1532242553 cites W2001399809 @default.
• W1532242553 cites W2002773065 @default.
• W1532242553 cites W2003410389 @default.
• W1532242553 cites W2003867300 @default.
• W1532242553 cites W2007953525 @default.
• W1532242553 cites W2010761126 @default.
• W1532242553 cites W2011896559 @default.
• W1532242553 cites W2012390743 @default.
• W1532242553 cites W2012440244 @default.
• W1532242553 cites W2017619665 @default.
• W1532242553 cites W2019145050 @default.
• W1532242553 cites W2019599792 @default.
• W1532242553 cites W2019678432 @default.
• W1532242553 cites W2020184457 @default.
• W1532242553 cites W2024790702 @default.
• W1532242553 cites W2025027835 @default.
• W1532242553 cites W2026403124 @default.
• W1532242553 cites W2026882865 @default.
• W1532242553 cites W2026951979 @default.
• W1532242553 cites W2028151158 @default.
• W1532242553 cites W2028415754 @default.
• W1532242553 cites W2031272027 @default.
• W1532242553 cites W2031283898 @default.
• W1532242553 cites W2032946042 @default.
• W1532242553 cites W2034580062 @default.

• next