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• W1532522639 abstract "Research Article20 December 1988free access The arginine repressor is essential for plasmid-stabilizing site-specific recombination at the ColE1 cer locus. C. J. Stirling C. J. Stirling Institute of Genetics, University of Glasgow, UK. Search for more papers by this author G. Szatmari G. Szatmari Institute of Genetics, University of Glasgow, UK. Search for more papers by this author G. Stewart G. Stewart Institute of Genetics, University of Glasgow, UK. Search for more papers by this author M. C. Smith M. C. Smith Institute of Genetics, University of Glasgow, UK. Search for more papers by this author D. J. Sherratt D. J. Sherratt Institute of Genetics, University of Glasgow, UK. Search for more papers by this author C. J. Stirling C. J. Stirling Institute of Genetics, University of Glasgow, UK. Search for more papers by this author G. Szatmari G. Szatmari Institute of Genetics, University of Glasgow, UK. Search for more papers by this author G. Stewart G. Stewart Institute of Genetics, University of Glasgow, UK. Search for more papers by this author M. C. Smith M. C. Smith Institute of Genetics, University of Glasgow, UK. Search for more papers by this author D. J. Sherratt D. J. Sherratt Institute of Genetics, University of Glasgow, UK. Search for more papers by this author Author Information C. J. Stirling1, G. Szatmari1, G. Stewart1, M. C. Smith1 and D. J. Sherratt1 1Institute of Genetics, University of Glasgow, UK. The EMBO Journal (1988)7:4389-4395https://doi.org/10.1002/j.1460-2075.1988.tb03338.x PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info The heritable stability in Escherichia coli of the multicopy plasmid ColE1 and its natural relatives requires that the plasmids be maintained in the monomeric state. Plasmid multimers, that arise through recA-dependent homologous recombination, are normally converted to monomers by a site-specific recombination system that acts at a specific plasmid site (cer in ColE1). No plasmid functions that act at this site have been identified. In contrast, two unlinked E.coli genes that encode functions required for cer-mediated site-specific recombination have been identified. Here we describe the isolation and characterization of one such gene (xerA) and show it to be identical to the gene encoding the repressor of the arginine biosynthetic genes (argR). The argR protein binds to cer DNA both in vivo and in vitro in the presence of arginine. We believe this binding is required to generate a higher order protein-DNA complex within the recombinational synapse. The argR gene of Bacillus subtilis complements an E.coli argR deficiency for cer-mediated recombination despite the two proteins having only 27% amino acid identity. Next ArticlePrevious Article Volume 7Issue 131 December 1988In this issue RelatedDetailsLoading ..." @default.
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• W1532522639 title "The arginine repressor is essential for plasmid-stabilizing site-specific recombination at the ColE1 cer locus." @default.
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• W1532522639 doi "https://doi.org/10.1002/j.1460-2075.1988.tb03338.x" @default.
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