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- W1532553592 abstract "Publisher Summary This chapter describes the clinical spectrum of the drug-induced hypersensitivity syndrome, the putative role of viral infection– especially the human-herpesvirus-6 (HHV-6) infection, its pathophysiology, and the clinical and therapeutic consequences of the implication of HHV-6 in this severe disease. Drug-induced hypersensitivity syndrome is a severe drug-induced reaction. Its clinical and biological manifestations are well characterized. Rashes were the most frequent manifestation, followed by fever, pharyngitis, lymphadenopathy, eosinophilia, hepatitis, and hematological abnormalities. It was observed that this adverse reaction was delayed in onset after drug initiation. This drug adverse reaction was first described with anticonvulsant as the “anticonvulsant hypersensitivity syndrome”, but other drugs, including allopurinol, minocycline, dapsone, sulfonamide antibiotics, nevirapine, abacavir, etc. may induce this reaction. These clinical and biological manifestations develop and may persist and progress for weeks after the offending drug is discontinued. The diagnosis of this syndrome may be confused with infection, lymphoma, hypereosinophilic syndrome, and collagen vascular disease. The acronym for drug reaction with eosinophilia and systemic symptoms (DRESS) was proposed to describe this syndrome. Study of DRESS offers a very good opportunity to understand the link between viral infection, drug allergy, and systemic symptoms." @default.
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- W1532553592 date "2006-01-01" @default.
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- W1532553592 title "Systemic Reactions to HHV-6 Infection" @default.
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- W1532553592 doi "https://doi.org/10.1016/s0168-7069(06)12011-x" @default.
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