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- W1532807611 abstract "It is estimated that by the year 2035 almost 600 million people will suffer from diabetes. In the case of type 2 diabetes, the strongest increase of diabetes incidence occurs in developing and newly industrialized countries. This increase correlates not only with a progressing sedentary lifestyle and nutritional changes, but also environmental changes. Similarly, the increase of type 1 diabetes incidence in industrialized countries over the past decades cannot be explained by genetic factors alone, suggesting that environmental changes are also involved. One such environmental change is a reduced exposure to pathogens because of improved hygiene. Parasitic helminths modulate the immune system of their hosts and induce type 2 as well as regulatory immune responses. As pro-inflammatory immune responses are crucial for the onset of both type 1 and type 2 diabetes, helminth-induced immunomodulation may prevent diabetes onset and ameliorate insulin sensitivity. Several epidemiological studies in human and experimental animal models support such a protective effect of helminths for autoimmune diabetes. Recent studies further suggest that helminths may also provide such a beneficial effect for type 2 diabetes. In this review we summarize studies that investigated parasitic helminths and helminth-derived products and their impact on both type 1 and type 2 diabetes highlighting potential protective mechanisms." @default.
- W1532807611 created "2016-06-24" @default.
- W1532807611 creator A5032857168 @default.
- W1532807611 creator A5033576692 @default.
- W1532807611 creator A5065292527 @default.
- W1532807611 creator A5071959267 @default.
- W1532807611 creator A5074218322 @default.
- W1532807611 date "2015-08-19" @default.
- W1532807611 modified "2023-09-30" @default.
- W1532807611 title "Parasitic helminths and their beneficial impact on type 1 and type 2 diabetes" @default.
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