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- W1532832054 endingPage "341" @default.
- W1532832054 startingPage "333" @default.
- W1532832054 abstract "Abstract Accumulation, aggregation and deposition of A β peptides are pathological hallmarks in the brains of individuals affected by A lzheimer's disease ( AD ) or by cerebral β‐amyloid angiopathy ( A β‐ CAA ). While A β is a peptide of yet largely unknown function, it is constantly produced in the human brain where it normally remains in a soluble state. However, A β peptides are aggregation prone by their intrinsic ability to adopt alternative conformations rich in β‐sheet structure that aggregate into oligomeric as well as fibrillar formations. This transition from soluble to aggregated state has been hypothesized to initiate the pathological cascade and is therefore subject to intensive research. Mounting evidence suggests prion‐like templated misfolding as the biochemical phenomenon responsible for promoting progressive A β aggregation. Here, we review studies in vitro and in vivo that suggest that cerebral A β aggregation may indeed progress via prion‐like templated misfolding. The implications of these findings are discussed with respect to understanding initiation and progression of the disease and to developing therapeutics." @default.
- W1532832054 created "2016-06-24" @default.
- W1532832054 creator A5040261788 @default.
- W1532832054 date "2013-04-16" @default.
- W1532832054 modified "2023-10-17" @default.
- W1532832054 title "From Soluble Aβ to Progressive Aβ Aggregation: Could Prion-Like Templated Misfolding Play a Role?" @default.
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