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- W1532904557 abstract "We have previously shown that d -cycloserine displaces [ 3 H]glycine binding to a recognition site with properties consistent with an N- methyl- d -aspartate (NMDA) receptor modulatory site. Additionally, d -cycloserine positively modulates the NMDA receptor as evidenced by its dose-dependent enhancement of [ 3 H]1-[1-(2-thienyl)cyclohexyl]piperidine ([ 3 H]TCP) binding to the NMDA receptor-coupled ionophore. Further evaluation of this compound indicates that the maximal stimulation of [ 3 H]TCP binding induced by d -cycloserine is lower than that produced by other compounds acting at the NMDA receptor associated glycine modulatory site (glycine and d -serine). Moreover, the stimulation of [ 3 H]TCP binding induced by d -cycloserine in the presence of various fixed concentrations of glycine results in a family of dose-response curves which asymptotically converge to 40–50% of the maximal stimulation induced by glycine alone. These results are consistent with d -cycloserine acting as a partial agonist of the NMDA receptor via its interaction with the coupled glycine modulatory site." @default.
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- W1532904557 date "1989-03-01" @default.
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- W1532904557 title "d-Cycloserine: A ligand for the coupled glycine receptor has partial agonist characteristics" @default.
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- W1532904557 doi "https://doi.org/10.1016/0304-3940(89)90379-0" @default.
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