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- W1532917355 abstract "Abstract Traumatic brain injury (TBI) is a multifaceted disease with intrinsically complex heterogeneity and remains a significant clinical challenge to manage. TBI model systems have demonstrated many mechanisms that contribute to brain parenchymal cell death, including glutamate and calcium toxicity, oxidative stress, inflammation, and mitochondrial dysfunction. Mitochondria are critically regulated by uncoupling proteins (UCP), which allow protons to leak back into the matrix and thus reduce the mitochondrial membrane potential by dissipating the proton motive force. This uncoupling of oxidative phosphorylation from adenosine triphosphate (ATP) synthesis is potentially critical for protection against cellular injury as a result of TBI and stroke. A greater understanding of the underlying mechanism or mechanisms by which uncoupling protein-2 (UCP2) functions to maintain or optimize mitochondrial function, and the conditions which precipitate the failure of these mechanisms, would inform future research and treatment strategies. We posit that UCP2-mediated function underlies the physiological response to neuronal stress associated with traumatic and ischemic injury and that clinical development of UCP2-targeted treatment would significantly impact these patient populations. With a focus on clinical relevance in TBI, we synthesize current knowledge concerning UCP2 and its potential neuroprotective role and apply this body of knowledge to current and potential treatment modalities." @default.
- W1532917355 created "2016-06-24" @default.
- W1532917355 creator A5009988205 @default.
- W1532917355 creator A5037598500 @default.
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- W1532917355 creator A5051414712 @default.
- W1532917355 creator A5056071422 @default.
- W1532917355 creator A5060781519 @default.
- W1532917355 date "2015-01-01" @default.
- W1532917355 modified "2023-09-28" @default.
- W1532917355 title "The emerging neuroprotective role of mitochondrial uncoupling protein-2 in traumatic brain injury" @default.
- W1532917355 cites W1554017667 @default.
- W1532917355 cites W1570689006 @default.
- W1532917355 cites W1594539479 @default.
- W1532917355 cites W1606398286 @default.
- W1532917355 cites W1784820495 @default.
- W1532917355 cites W1846092430 @default.
- W1532917355 cites W1849928642 @default.
- W1532917355 cites W1875250937 @default.
- W1532917355 cites W1900866157 @default.
- W1532917355 cites W1921965616 @default.
- W1532917355 cites W1962155705 @default.
- W1532917355 cites W1964483580 @default.
- W1532917355 cites W1970992446 @default.
- W1532917355 cites W1975515886 @default.
- W1532917355 cites W1976710020 @default.
- W1532917355 cites W1976881265 @default.
- W1532917355 cites W1977983510 @default.
- W1532917355 cites W1980779044 @default.
- W1532917355 cites W1980959570 @default.
- W1532917355 cites W1983502552 @default.
- W1532917355 cites W1984658784 @default.
- W1532917355 cites W1985031521 @default.
- W1532917355 cites W1986219537 @default.
- W1532917355 cites W1986333935 @default.
- W1532917355 cites W1987639430 @default.
- W1532917355 cites W1987981231 @default.
- W1532917355 cites W1988783332 @default.
- W1532917355 cites W1988856395 @default.
- W1532917355 cites W1991238715 @default.
- W1532917355 cites W1991893128 @default.
- W1532917355 cites W1993039541 @default.
- W1532917355 cites W1993877143 @default.
- W1532917355 cites W1994191301 @default.
- W1532917355 cites W1996568613 @default.
- W1532917355 cites W1998084948 @default.
- W1532917355 cites W1998397069 @default.
- W1532917355 cites W1999946108 @default.
- W1532917355 cites W2000057840 @default.
- W1532917355 cites W2001018391 @default.
- W1532917355 cites W2001637884 @default.
- W1532917355 cites W2002716364 @default.
- W1532917355 cites W2003773486 @default.
- W1532917355 cites W2007626857 @default.
- W1532917355 cites W20087376 @default.
- W1532917355 cites W2011042390 @default.
- W1532917355 cites W2013992962 @default.
- W1532917355 cites W2014602095 @default.
- W1532917355 cites W2015221597 @default.
- W1532917355 cites W2024267786 @default.
- W1532917355 cites W2026035029 @default.
- W1532917355 cites W2026856755 @default.
- W1532917355 cites W2027950911 @default.
- W1532917355 cites W2028132430 @default.
- W1532917355 cites W2028508182 @default.
- W1532917355 cites W2029235482 @default.
- W1532917355 cites W2032814494 @default.
- W1532917355 cites W2034430821 @default.
- W1532917355 cites W2034471432 @default.
- W1532917355 cites W2036573181 @default.
- W1532917355 cites W2037075564 @default.
- W1532917355 cites W2040799021 @default.
- W1532917355 cites W2045838525 @default.
- W1532917355 cites W2049866896 @default.
- W1532917355 cites W2050297509 @default.
- W1532917355 cites W2050705798 @default.
- W1532917355 cites W2054376401 @default.
- W1532917355 cites W2055379426 @default.
- W1532917355 cites W2056145463 @default.
- W1532917355 cites W2057973123 @default.
- W1532917355 cites W2062344501 @default.
- W1532917355 cites W2067593902 @default.
- W1532917355 cites W2069991801 @default.
- W1532917355 cites W2073017812 @default.
- W1532917355 cites W2073765502 @default.
- W1532917355 cites W2075343775 @default.
- W1532917355 cites W2079310705 @default.
- W1532917355 cites W2081173970 @default.
- W1532917355 cites W2081250995 @default.
- W1532917355 cites W2084066290 @default.
- W1532917355 cites W2090027652 @default.
- W1532917355 cites W2094070434 @default.
- W1532917355 cites W2095816719 @default.
- W1532917355 cites W2111757377 @default.
- W1532917355 cites W2112947221 @default.
- W1532917355 cites W2122703782 @default.
- W1532917355 cites W2123289930 @default.
- W1532917355 cites W2123338440 @default.