Matches in SemOpenAlex for { <https://semopenalex.org/work/W1532977449> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W1532977449 endingPage "1812" @default.
- W1532977449 startingPage "1810" @default.
- W1532977449 abstract "Forty preparations of the extracts from 28 kinds of Asian herbs were tested for ability to inhibit the activities of murine retroviral reverse transcriptase and human deoxyribonucleic acid (DNA) polymerases. Among the 40 extracts, 35 inhibited reverse transcriptase activity and 29 inhibited DNA polymerase α activity. The inhibitory potencies of these extracts were expressed as the 50% inhibition concentrations (IC50), at which the enzyme activities were inhibited by 50%. Very strong inhibitions were observed with the extracts from Millettia pachycarpa (Leguminosae) and Mallotus apelta (Euphorbiaceae) as shown by their low IC50 values for reverse transcriptase (0.4-0.5 μg/ml) and DNA polymerase α(0.9-1.4 μg/ml). Enzyme kinetic analysis revealed that the mode of inhibition of reverse transcriptase by these two extracts was competitive with respect to the template·primer [poly(rA)·oligo(dT)] and noncompetitive with respect to deoxythymidine triphosphate (dTTP) substrate. Besides reverse transcriptase and DNA polymerase α, DNA polymerase I and ribonucleic acid (RNA) polymerase from E. coli were inhibited by these two extracts. These results indicate that the herb extracts contain as yet unidentified substance(s) which inhibit the activities of reverse transcriptase and cellular DNA polymerases." @default.
- W1532977449 created "2016-06-24" @default.
- W1532977449 creator A5000584891 @default.
- W1532977449 creator A5001272022 @default.
- W1532977449 creator A5015026719 @default.
- W1532977449 creator A5017959526 @default.
- W1532977449 creator A5019477802 @default.
- W1532977449 creator A5081912530 @default.
- W1532977449 date "1989-01-01" @default.
- W1532977449 modified "2023-10-14" @default.
- W1532977449 title "Differential inhibitory effects of various herb extracts on the activities of reverse transcriptase and various deoxyribonucleic acid(DNA) polymerases." @default.
- W1532977449 doi "https://doi.org/10.1248/cpb.37.1810" @default.
- W1532977449 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2478305" @default.
- W1532977449 hasPublicationYear "1989" @default.
- W1532977449 type Work @default.
- W1532977449 sameAs 1532977449 @default.
- W1532977449 citedByCount "43" @default.
- W1532977449 countsByYear W15329774492012 @default.
- W1532977449 countsByYear W15329774492013 @default.
- W1532977449 countsByYear W15329774492014 @default.
- W1532977449 countsByYear W15329774492015 @default.
- W1532977449 countsByYear W15329774492018 @default.
- W1532977449 countsByYear W15329774492019 @default.
- W1532977449 countsByYear W15329774492020 @default.
- W1532977449 countsByYear W15329774492021 @default.
- W1532977449 countsByYear W15329774492022 @default.
- W1532977449 countsByYear W15329774492023 @default.
- W1532977449 crossrefType "journal-article" @default.
- W1532977449 hasAuthorship W1532977449A5000584891 @default.
- W1532977449 hasAuthorship W1532977449A5001272022 @default.
- W1532977449 hasAuthorship W1532977449A5015026719 @default.
- W1532977449 hasAuthorship W1532977449A5017959526 @default.
- W1532977449 hasAuthorship W1532977449A5019477802 @default.
- W1532977449 hasAuthorship W1532977449A5081912530 @default.
- W1532977449 hasBestOaLocation W15329774491 @default.
- W1532977449 hasConcept C104317684 @default.
- W1532977449 hasConcept C153574943 @default.
- W1532977449 hasConcept C153911025 @default.
- W1532977449 hasConcept C156719811 @default.
- W1532977449 hasConcept C164965036 @default.
- W1532977449 hasConcept C178790620 @default.
- W1532977449 hasConcept C181199279 @default.
- W1532977449 hasConcept C185592680 @default.
- W1532977449 hasConcept C2756471 @default.
- W1532977449 hasConcept C2777563447 @default.
- W1532977449 hasConcept C2910803801 @default.
- W1532977449 hasConcept C552990157 @default.
- W1532977449 hasConcept C55493867 @default.
- W1532977449 hasConcept C67705224 @default.
- W1532977449 hasConcept C82381507 @default.
- W1532977449 hasConcept C86803240 @default.
- W1532977449 hasConceptScore W1532977449C104317684 @default.
- W1532977449 hasConceptScore W1532977449C153574943 @default.
- W1532977449 hasConceptScore W1532977449C153911025 @default.
- W1532977449 hasConceptScore W1532977449C156719811 @default.
- W1532977449 hasConceptScore W1532977449C164965036 @default.
- W1532977449 hasConceptScore W1532977449C178790620 @default.
- W1532977449 hasConceptScore W1532977449C181199279 @default.
- W1532977449 hasConceptScore W1532977449C185592680 @default.
- W1532977449 hasConceptScore W1532977449C2756471 @default.
- W1532977449 hasConceptScore W1532977449C2777563447 @default.
- W1532977449 hasConceptScore W1532977449C2910803801 @default.
- W1532977449 hasConceptScore W1532977449C552990157 @default.
- W1532977449 hasConceptScore W1532977449C55493867 @default.
- W1532977449 hasConceptScore W1532977449C67705224 @default.
- W1532977449 hasConceptScore W1532977449C82381507 @default.
- W1532977449 hasConceptScore W1532977449C86803240 @default.
- W1532977449 hasIssue "7" @default.
- W1532977449 hasLocation W15329774491 @default.
- W1532977449 hasLocation W15329774492 @default.
- W1532977449 hasOpenAccess W1532977449 @default.
- W1532977449 hasPrimaryLocation W15329774491 @default.
- W1532977449 hasRelatedWork W1532977449 @default.
- W1532977449 hasRelatedWork W1968435522 @default.
- W1532977449 hasRelatedWork W1991882936 @default.
- W1532977449 hasRelatedWork W2002978048 @default.
- W1532977449 hasRelatedWork W2028824527 @default.
- W1532977449 hasRelatedWork W2034458000 @default.
- W1532977449 hasRelatedWork W2058631315 @default.
- W1532977449 hasRelatedWork W2068450351 @default.
- W1532977449 hasRelatedWork W2136629717 @default.
- W1532977449 hasRelatedWork W2164625231 @default.
- W1532977449 hasVolume "37" @default.
- W1532977449 isParatext "false" @default.
- W1532977449 isRetracted "false" @default.
- W1532977449 magId "1532977449" @default.
- W1532977449 workType "article" @default.