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- W1533032912 abstract "Given our evolving understanding of the molecular events mediating resistance in CML and Ph+ ALL, standards for reporting of BCR-ABL mutational studies would benefit from a greater degree of uniformity. Commercially-available reference samples and calibrators as well as a publicly available BCR-ABL mutation database are the currently needed resources to allow laboratories and clinicians to interpret the significance of BCR-ABL KD mutation studies. While these standardization efforts are proceeding, mutation studies should be based on the already developed criteria for clinical resistance (summarized above) to better ensure appropriate utilization. As shared databases become more widely available, the most appropriate statements regarding the clinical significance of specific mutations will be better defined and allow more precise guidance to be given." @default.
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- W1533032912 date "2009-01-01" @default.
- W1533032912 modified "2023-09-28" @default.
- W1533032912 title "Laboratory Practice Guidelines for Detecting and Reporting BCR-ABL Drug Resistance Mutations in Chronic Myelogenous Leukemia and Acute Lymphoblastic Leukemia" @default.
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- W1533032912 doi "https://doi.org/10.2353/jmoldx.2009.080095" @default.
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