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• W1533067296 abstract "iv CHAPTER 1: GENERAL INTRODUCTION 1 1.1 SNARE PROTEINS AND MEMBRANE FUSION 1 1.2 THE SNARE HYPOTHESIS: THE MINIMAL FUSION MACHINERY 2 1.3 THE SNARE ASSEMBLY PATHWAY AND THE ZIPPERING MODEL 3 1.4 MODELS FOR MEMBRANE FUSION 4 1.5 THE SNARE-INTERACTING PROTEINS 5 1.5.1 Clostridial neurotoxins 5 1.5.2 Synaptotagmin 6 1.5.3 Complexin 7 1.6 STUDY METHODS 8 1.6.1 SDSL and EPR 8 1.6.2 Ensemble lipid mixing assay 9 1.6.3 Single-vesicle fusion assay 9 1.7 REFERENCES 10 1.8 FIGURES AND CAPTIONS 17 CHAPTER 2: ACCESSORY α-HELIX OF COMPLEXIN I CAN DISPLACE VAMP2 LOCALLY IN THE COMPLEXIN-SNARE QUATERNARY COMPLEX 31 2.1 ABSTRACT 31 2.2 INTRODUCTION 32 2.3 MATERIALS AND METHODS 33 2.4 RESULTS 35 2.5 DISCUSSION 39 2.6 REFERENCES 41 2.7 FIGURES AND CAPTIONS 46 2.8 SUPPLEMENTARY DATA 50" @default.
• W1533067296 created "2016-06-24" @default.
• W1533067296 creator A5045672322 @default.
• W1533067296 date "2018-08-10" @default.
• W1533067296 modified "2023-10-16" @default.
• W1533067296 title "Investigation of the molecular mechanism of SNARE-mediated membrane fusion" @default.
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