Matches in SemOpenAlex for { <https://semopenalex.org/work/W1533067306> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W1533067306 startingPage "19" @default.
- W1533067306 abstract "Extracellular Ca2+, at concentrations exceeding 10 mmol/l, causes a dose-related stimulation of insulin release. The dynamics of Ca2+-induced insulin release are characterized by a quick onset, a progressive build-up and a later return towards basal secretory rate. The release of insulin evoked by Ca2+ is inhibited in the presence of either Mg2+ (10 mmol/l) or the organic Ca2+-antagonist verapamil (81 μmol/l), both of which are known to inhibit Ca2+ entry in the B-cell. Glucose and theophylline, which are thought to affect the net uptake or intracellular distribution of Ca2+ in the B-cell, both enhance Ca2+-induced insulin release. As little as 2.7 mmol/l glucose is sufficient to augment Ca2+-induced insulin secretion. Exposure of the pancreas to somatostatin significantly retards the secretory response to Ca2+. Cytochalasin B potentiates the insulin release evoked by Ca2+ (12 mmol/l) and lowers the threshold concentration of Ca2+ required to stimulate secretion. These data suggest that high extracellular Ca2+ concentrations may sufficiently increase the amount of Ca2+ accumulated in the B-cell to eventually trigger insulin release. Agents known to cause a remodelling of Ca2+ fluxes across membrane systems in the B-cell interfere with Ca2+-induced insulin release, a process also dependent on the integrity of the cytochalasin B-sensitive microfilamentous effector system." @default.
- W1533067306 created "2016-06-24" @default.
- W1533067306 creator A5020829082 @default.
- W1533067306 creator A5048117526 @default.
- W1533067306 creator A5089989861 @default.
- W1533067306 date "1977-01-01" @default.
- W1533067306 modified "2023-09-23" @default.
- W1533067306 title "Dynamics of calcium-induced insulin release" @default.
- W1533067306 hasPublicationYear "1977" @default.
- W1533067306 type Work @default.
- W1533067306 sameAs 1533067306 @default.
- W1533067306 citedByCount "0" @default.
- W1533067306 crossrefType "journal-article" @default.
- W1533067306 hasAuthorship W1533067306A5020829082 @default.
- W1533067306 hasAuthorship W1533067306A5048117526 @default.
- W1533067306 hasAuthorship W1533067306A5089989861 @default.
- W1533067306 hasConcept C126322002 @default.
- W1533067306 hasConcept C134018914 @default.
- W1533067306 hasConcept C142669718 @default.
- W1533067306 hasConcept C1491633281 @default.
- W1533067306 hasConcept C185592680 @default.
- W1533067306 hasConcept C2775995422 @default.
- W1533067306 hasConcept C2777022698 @default.
- W1533067306 hasConcept C2779012151 @default.
- W1533067306 hasConcept C2779306644 @default.
- W1533067306 hasConcept C28406088 @default.
- W1533067306 hasConcept C519063684 @default.
- W1533067306 hasConcept C55493867 @default.
- W1533067306 hasConcept C71924100 @default.
- W1533067306 hasConcept C79879829 @default.
- W1533067306 hasConcept C86803240 @default.
- W1533067306 hasConceptScore W1533067306C126322002 @default.
- W1533067306 hasConceptScore W1533067306C134018914 @default.
- W1533067306 hasConceptScore W1533067306C142669718 @default.
- W1533067306 hasConceptScore W1533067306C1491633281 @default.
- W1533067306 hasConceptScore W1533067306C185592680 @default.
- W1533067306 hasConceptScore W1533067306C2775995422 @default.
- W1533067306 hasConceptScore W1533067306C2777022698 @default.
- W1533067306 hasConceptScore W1533067306C2779012151 @default.
- W1533067306 hasConceptScore W1533067306C2779306644 @default.
- W1533067306 hasConceptScore W1533067306C28406088 @default.
- W1533067306 hasConceptScore W1533067306C519063684 @default.
- W1533067306 hasConceptScore W1533067306C55493867 @default.
- W1533067306 hasConceptScore W1533067306C71924100 @default.
- W1533067306 hasConceptScore W1533067306C79879829 @default.
- W1533067306 hasConceptScore W1533067306C86803240 @default.
- W1533067306 hasOpenAccess W1533067306 @default.
- W1533067306 hasRelatedWork W1581436439 @default.
- W1533067306 hasRelatedWork W1672106329 @default.
- W1533067306 hasRelatedWork W1718566928 @default.
- W1533067306 hasRelatedWork W1756627376 @default.
- W1533067306 hasRelatedWork W1981747327 @default.
- W1533067306 hasRelatedWork W1986014140 @default.
- W1533067306 hasRelatedWork W2006329375 @default.
- W1533067306 hasRelatedWork W2020726723 @default.
- W1533067306 hasRelatedWork W2024247594 @default.
- W1533067306 hasRelatedWork W2027651425 @default.
- W1533067306 hasRelatedWork W2036372427 @default.
- W1533067306 hasRelatedWork W2080621762 @default.
- W1533067306 hasRelatedWork W2088620219 @default.
- W1533067306 hasRelatedWork W2092787712 @default.
- W1533067306 hasRelatedWork W2109269035 @default.
- W1533067306 hasRelatedWork W2155543231 @default.
- W1533067306 hasRelatedWork W2209915127 @default.
- W1533067306 hasRelatedWork W2407840244 @default.
- W1533067306 hasRelatedWork W2988964749 @default.
- W1533067306 hasRelatedWork W2551688205 @default.
- W1533067306 hasVolume "7" @default.
- W1533067306 isParatext "false" @default.
- W1533067306 isRetracted "false" @default.
- W1533067306 magId "1533067306" @default.
- W1533067306 workType "article" @default.