FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1533084826> ?p ?o ?g. }

• W1533084826 endingPage "1530" @default.
• W1533084826 startingPage "1520" @default.
• W1533084826 abstract "Background Refrigeration of platelets (PLTs) offers an attractive alternative to the currently practiced storage at room temperature since it may mitigate problems associated with bacterial contamination and extend storage lifetime. Refrigeration causes a number of biophysical and biochemical changes in PLTs and decreases PLT circulation time in vivo. However, the effect of refrigeration on PLT hemostatic functions under physiologic and pathophysiologic shear conditions has not been adequately characterized. Study Design and Methods Washed PLTs prepared from either fresh PLT-rich plasma (PRP) or PRP stored at 4°C for 2 days was mixed with exogenous von Willebrand factor (VWF) and fibrinogen and sheared in a cone-and-plate viscometer. PLT aggregation, activation, and VWF binding after shear and glycoprotein (GP) Ibα receptor expression and ristocetin-induced PLT agglutination were measured. Results PLTs stored at 4°C for 2 days aggregated significantly more than fresh PLTs particularly at high shear rates (10,000/sec), and this increase was independent of PLT concentration or suspension viscosity. Further, refrigerated PLTs showed a greater increase in GP Ibα–dependent PLT activation under shear and also bound more VWF than fresh PLTs. However, the GP Ibα expression levels as measured by three different antibodies were significantly lower in refrigerated PLTs than in fresh PLTs, and refrigeration resulted in a modest decrease in ristocetin-induced PLT agglutination. Conclusion The combined results demonstrate that refrigeration increases PLT aggregation under high shear, but not static, conditions and also increases shear-induced VWF binding and PLT activation. Clinically, enhanced shear-induced PLT aggregation due to low temperature storage may be a beneficial strategy to prevent severe bleeding in trauma." @default.
• W1533084826 created "2016-06-24" @default.
• W1533084826 creator A5002860501 @default.
• W1533084826 creator A5009498984 @default.
• W1533084826 creator A5030156969 @default.
• W1533084826 creator A5086645862 @default.
• W1533084826 creator A5087505554 @default.
• W1533084826 date "2012-10-09" @default.
• W1533084826 modified "2023-10-18" @default.
• W1533084826 title "Enhanced shear-induced platelet aggregation due to low-temperature storage" @default.
• W1533084826 cites W16089093 @default.
• W1533084826 cites W1881826640 @default.
• W1533084826 cites W1969223552 @default.
• W1533084826 cites W1979829974 @default.
• W1533084826 cites W1980955058 @default.
• W1533084826 cites W1984795026 @default.
• W1533084826 cites W1988017355 @default.
• W1533084826 cites W1994660709 @default.
• W1533084826 cites W1996510020 @default.
• W1533084826 cites W1997837166 @default.
• W1533084826 cites W2000073370 @default.
• W1533084826 cites W2011256001 @default.
• W1533084826 cites W2014055294 @default.
• W1533084826 cites W2029837592 @default.
• W1533084826 cites W2036904069 @default.
• W1533084826 cites W2040170208 @default.
• W1533084826 cites W2050286876 @default.
• W1533084826 cites W2051461289 @default.
• W1533084826 cites W2053043651 @default.
• W1533084826 cites W2060935167 @default.
• W1533084826 cites W2069025442 @default.
• W1533084826 cites W2071260329 @default.
• W1533084826 cites W2079023317 @default.
• W1533084826 cites W2089063331 @default.
• W1533084826 cites W2105636185 @default.
• W1533084826 cites W2147063334 @default.
• W1533084826 cites W2147290071 @default.
• W1533084826 cites W2158551846 @default.
• W1533084826 cites W2159308912 @default.
• W1533084826 cites W2171068060 @default.
• W1533084826 cites W2236786177 @default.
• W1533084826 cites W2305127727 @default.
• W1533084826 doi "https://doi.org/10.1111/j.1537-2995.2012.03917.x" @default.
• W1533084826 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4321779" @default.
• W1533084826 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23043289" @default.
• W1533084826 hasPublicationYear "2012" @default.
• W1533084826 type Work @default.
• W1533084826 sameAs 1533084826 @default.
• W1533084826 citedByCount "62" @default.
• W1533084826 countsByYear W15330848262013 @default.
• W1533084826 countsByYear W15330848262014 @default.
• W1533084826 countsByYear W15330848262015 @default.
• W1533084826 countsByYear W15330848262016 @default.
• W1533084826 countsByYear W15330848262017 @default.
• W1533084826 countsByYear W15330848262018 @default.
• W1533084826 countsByYear W15330848262019 @default.
• W1533084826 countsByYear W15330848262020 @default.
• W1533084826 countsByYear W15330848262021 @default.
• W1533084826 countsByYear W15330848262022 @default.
• W1533084826 countsByYear W15330848262023 @default.
• W1533084826 crossrefType "journal-article" @default.
• W1533084826 hasAuthorship W1533084826A5002860501 @default.
• W1533084826 hasAuthorship W1533084826A5009498984 @default.
• W1533084826 hasAuthorship W1533084826A5030156969 @default.
• W1533084826 hasAuthorship W1533084826A5086645862 @default.
• W1533084826 hasAuthorship W1533084826A5087505554 @default.
• W1533084826 hasBestOaLocation W15330848262 @default.
• W1533084826 hasConcept C12554922 @default.
• W1533084826 hasConcept C143508840 @default.
• W1533084826 hasConcept C159654299 @default.
• W1533084826 hasConcept C159985019 @default.
• W1533084826 hasConcept C185592680 @default.
• W1533084826 hasConcept C192562407 @default.
• W1533084826 hasConcept C203014093 @default.
• W1533084826 hasConcept C2776057759 @default.
• W1533084826 hasConcept C2779394231 @default.
• W1533084826 hasConcept C71924100 @default.
• W1533084826 hasConcept C86803240 @default.
• W1533084826 hasConcept C89560881 @default.
• W1533084826 hasConcept C96035792 @default.
• W1533084826 hasConceptScore W1533084826C12554922 @default.
• W1533084826 hasConceptScore W1533084826C143508840 @default.
• W1533084826 hasConceptScore W1533084826C159654299 @default.
• W1533084826 hasConceptScore W1533084826C159985019 @default.
• W1533084826 hasConceptScore W1533084826C185592680 @default.
• W1533084826 hasConceptScore W1533084826C192562407 @default.
• W1533084826 hasConceptScore W1533084826C203014093 @default.
• W1533084826 hasConceptScore W1533084826C2776057759 @default.
• W1533084826 hasConceptScore W1533084826C2779394231 @default.
• W1533084826 hasConceptScore W1533084826C71924100 @default.
• W1533084826 hasConceptScore W1533084826C86803240 @default.
• W1533084826 hasConceptScore W1533084826C89560881 @default.
• W1533084826 hasConceptScore W1533084826C96035792 @default.
• W1533084826 hasIssue "7" @default.
• W1533084826 hasLocation W15330848261 @default.
• W1533084826 hasLocation W15330848262 @default.
• W1533084826 hasLocation W15330848263 @default.
• W1533084826 hasLocation W15330848264 @default.

• next