Matches in SemOpenAlex for { <https://semopenalex.org/work/W1533137732> ?p ?o ?g. }
- W1533137732 endingPage "335" @default.
- W1533137732 startingPage "327" @default.
- W1533137732 abstract "This laboratory has studied the enzymology involved in the biotransformation of inorganic arsenic to dimethylarsinous acid (DMA(III)) and in human studies established that monomethylarsonous acid (MMA(III)) and DMA(III) appear in urine of people chronically exposed to arsenic. It appears that only two proteins are required for inorganic arsenic biotransformation in the human, namely, monomethylarsonic acid (MMA(V)) reductase and arsenic methyltransferase. MMA(V) reductase and the unique glutathione transferase omega (hGST-O) are identical proteins. Arsenicals with a +3 oxidation state are more toxic than the +5 species. While methylation of arsenite, MMA(III), and DMA(III) produces less toxic +5 oxidation arsenic species containing an additional methyl group such as MMA(V), dimethylarsinic acid (DMA(V)), and TMAO, a new mechanism involving hydrogen peroxide for detoxifying arsenite, MMA(III), and DMA(III) is proposed based on in vitro experiments." @default.
- W1533137732 created "2016-06-24" @default.
- W1533137732 creator A5021233362 @default.
- W1533137732 creator A5032126971 @default.
- W1533137732 creator A5052748512 @default.
- W1533137732 creator A5075882805 @default.
- W1533137732 creator A5081925894 @default.
- W1533137732 date "2004-08-01" @default.
- W1533137732 modified "2023-10-02" @default.
- W1533137732 title "A review of the enzymology of arsenic metabolism and a new potential role of hydrogen peroxide in the detoxication of the trivalent arsenic species" @default.
- W1533137732 cites W1479912346 @default.
- W1533137732 cites W1482923693 @default.
- W1533137732 cites W1705780367 @default.
- W1533137732 cites W1745280408 @default.
- W1533137732 cites W1777939053 @default.
- W1533137732 cites W1828830410 @default.
- W1533137732 cites W1918363838 @default.
- W1533137732 cites W1967850583 @default.
- W1533137732 cites W1968145127 @default.
- W1533137732 cites W1972754197 @default.
- W1533137732 cites W1973875276 @default.
- W1533137732 cites W1976690731 @default.
- W1533137732 cites W1977896790 @default.
- W1533137732 cites W1978665041 @default.
- W1533137732 cites W1979861889 @default.
- W1533137732 cites W1982330330 @default.
- W1533137732 cites W1985800606 @default.
- W1533137732 cites W1990994253 @default.
- W1533137732 cites W1996123491 @default.
- W1533137732 cites W2004835835 @default.
- W1533137732 cites W2005492763 @default.
- W1533137732 cites W2007042296 @default.
- W1533137732 cites W2012765572 @default.
- W1533137732 cites W2018539752 @default.
- W1533137732 cites W2022859493 @default.
- W1533137732 cites W2028855377 @default.
- W1533137732 cites W2029583268 @default.
- W1533137732 cites W2037960524 @default.
- W1533137732 cites W2040606164 @default.
- W1533137732 cites W2044149640 @default.
- W1533137732 cites W2044597069 @default.
- W1533137732 cites W2044742552 @default.
- W1533137732 cites W2045245826 @default.
- W1533137732 cites W2045823138 @default.
- W1533137732 cites W2046444528 @default.
- W1533137732 cites W2047439811 @default.
- W1533137732 cites W2053658205 @default.
- W1533137732 cites W2060187730 @default.
- W1533137732 cites W2065138265 @default.
- W1533137732 cites W2065170814 @default.
- W1533137732 cites W2067283868 @default.
- W1533137732 cites W2073985048 @default.
- W1533137732 cites W2075243259 @default.
- W1533137732 cites W2079987670 @default.
- W1533137732 cites W2081371563 @default.
- W1533137732 cites W2086201153 @default.
- W1533137732 cites W2089037794 @default.
- W1533137732 cites W2094568038 @default.
- W1533137732 cites W2098285182 @default.
- W1533137732 cites W2104926479 @default.
- W1533137732 cites W2136310944 @default.
- W1533137732 cites W2141549113 @default.
- W1533137732 cites W2145410789 @default.
- W1533137732 cites W2145524273 @default.
- W1533137732 cites W2153412566 @default.
- W1533137732 cites W2154622266 @default.
- W1533137732 cites W2167586301 @default.
- W1533137732 cites W2395613329 @default.
- W1533137732 cites W41563388 @default.
- W1533137732 cites W579325749 @default.
- W1533137732 doi "https://doi.org/10.1016/j.taap.2003.10.027" @default.
- W1533137732 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15276412" @default.
- W1533137732 hasPublicationYear "2004" @default.
- W1533137732 type Work @default.
- W1533137732 sameAs 1533137732 @default.
- W1533137732 citedByCount "201" @default.
- W1533137732 countsByYear W15331377322012 @default.
- W1533137732 countsByYear W15331377322013 @default.
- W1533137732 countsByYear W15331377322014 @default.
- W1533137732 countsByYear W15331377322015 @default.
- W1533137732 countsByYear W15331377322016 @default.
- W1533137732 countsByYear W15331377322017 @default.
- W1533137732 countsByYear W15331377322018 @default.
- W1533137732 countsByYear W15331377322019 @default.
- W1533137732 countsByYear W15331377322020 @default.
- W1533137732 countsByYear W15331377322021 @default.
- W1533137732 countsByYear W15331377322022 @default.
- W1533137732 countsByYear W15331377322023 @default.
- W1533137732 crossrefType "journal-article" @default.
- W1533137732 hasAuthorship W1533137732A5021233362 @default.
- W1533137732 hasAuthorship W1533137732A5032126971 @default.
- W1533137732 hasAuthorship W1533137732A5052748512 @default.
- W1533137732 hasAuthorship W1533137732A5075882805 @default.
- W1533137732 hasAuthorship W1533137732A5081925894 @default.
- W1533137732 hasConcept C178790620 @default.
- W1533137732 hasConcept C181199279 @default.
- W1533137732 hasConcept C185592680 @default.
- W1533137732 hasConcept C2776305511 @default.