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- W1533151908 abstract "The frequencies of seventeen cell types in smears taken in clinically healthy areas of ten regions of the oral mucosa were compared in thirty-seven nonsmokers and forty-one heavy smokers. The subjects were men between 30 and 50 years of age. Smears were processed by the Papanicolaou technique, and 100 serial cells per smear were classified. Smoking was found to affect the frequency of almost all cell types in each of the ten regions. In nine of ten regions, smokers showed a shift toward less mature cell types. In three keratinized regions and in two regions with intermediate degrees of keratinization, the frequency of cells with orange cytoplasm decreased. In four nonkeratinized regions, the frequency of cells with pink cytoplasm decreased. Balancing increases in the keratinized regions occurred in the less mature cells with only partly orange but partly still pink cytoplasm, while in the non-keratinized regions the greatest increases were seen in the least mature of the cell types with blue cytoplasm. Thus, by contrast to the hyperkeratotic lesions clinically associated with the use of tobacco, the earliest effects of smoking, preceding clinical changes, are a shift from cells with higher degrees of keratinization to cells with lower degrees." @default.
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- W1533151908 date "1970-11-01" @default.
- W1533151908 modified "2023-09-27" @default.
- W1533151908 title "Early effects of smoking on surface cytology of the oral mucosa" @default.
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- W1533151908 doi "https://doi.org/10.1016/0030-4220(70)90397-x" @default.
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