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- W1533251519 abstract "Significance IFN-γ is a proinflammatory cytokine and stimulates induction of ∼2,000 genes, including IFN-γ–inducible GTPases, such as immunity-related GTPases (IRGs) and guanylate-binding proteins (GBPs), that are critically required for cell-autonomous host defense against the vacuolar pathogen Toxoplasma gondii . Mechanisms of how recruitment of these GTPases to the vacuoles is positively regulated have been gradually elucidated. However, the negative regulation remains unknown. Here, we show that Rab GDP dissociation inhibitor α (RabGDIα) acts as a suppressor of IFN-γ–inducible GTPases, such as Gbp2 and Irga6. RabGDIα deficiency resulted in enhanced IFN-γ–mediated T. gondii clearance in vitro and in vivo. Furthermore, RabGDIα inhibited the act of Gbp2 and Irga6 through the lipid-binding pocket. Thus, our current study demonstrates a negative regulatory mechanism for IFN-γ–inducible GTPase-dependent cell-autonomous immunity." @default.
- W1533251519 created "2016-06-24" @default.
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- W1533251519 creator A5079760360 @default.
- W1533251519 date "2015-08-03" @default.
- W1533251519 modified "2023-10-18" @default.
- W1533251519 title "RabGDIα is a negative regulator of interferon-γ–inducible GTPase-dependent cell-autonomous immunity to <i>Toxoplasma gondii</i>" @default.
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- W1533251519 cites W1521556649 @default.
- W1533251519 cites W1534709281 @default.
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- W1533251519 cites W1963848219 @default.
- W1533251519 cites W1964802617 @default.
- W1533251519 cites W1970279912 @default.
- W1533251519 cites W1970998121 @default.
- W1533251519 cites W1973723338 @default.
- W1533251519 cites W1977409139 @default.
- W1533251519 cites W1978466652 @default.
- W1533251519 cites W1981066202 @default.
- W1533251519 cites W1981783595 @default.
- W1533251519 cites W1987348808 @default.
- W1533251519 cites W1987371296 @default.
- W1533251519 cites W1991354028 @default.
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- W1533251519 cites W1992762970 @default.
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- W1533251519 cites W2008138629 @default.
- W1533251519 cites W2009101093 @default.
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- W1533251519 cites W2016865932 @default.
- W1533251519 cites W2019478986 @default.
- W1533251519 cites W2019500286 @default.
- W1533251519 cites W2028552491 @default.
- W1533251519 cites W2031029755 @default.
- W1533251519 cites W2031913105 @default.
- W1533251519 cites W2035273201 @default.
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- W1533251519 cites W2058235794 @default.
- W1533251519 cites W2059203800 @default.
- W1533251519 cites W2064456932 @default.
- W1533251519 cites W2066217023 @default.
- W1533251519 cites W2066598824 @default.
- W1533251519 cites W2066649997 @default.
- W1533251519 cites W2068187450 @default.
- W1533251519 cites W2069031003 @default.
- W1533251519 cites W2069498930 @default.
- W1533251519 cites W2076319724 @default.
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- W1533251519 cites W2117163574 @default.
- W1533251519 cites W2118434776 @default.
- W1533251519 cites W2119087770 @default.
- W1533251519 cites W2129052947 @default.
- W1533251519 cites W2134768631 @default.
- W1533251519 cites W2137175516 @default.
- W1533251519 cites W2140990000 @default.
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- W1533251519 doi "https://doi.org/10.1073/pnas.1510031112" @default.
- W1533251519 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4547277" @default.
- W1533251519 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26240314" @default.
- W1533251519 hasPublicationYear "2015" @default.
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