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- W1533253593 abstract "This chapter discusses scintigraphic techniques for investigating the in vivo behavior of liposomes. The major advantage of scintigraphy is its ability to obtain images over a longer time, which rapidly gives an impression of the in vivo behavior of the liposomes without the need for dissecting a large number of animals. The most fundamental method is to encapsulate the radiolabel in the aqueous interior during the hydration of the lipids of the liposomes. This method is laborious and has a low labeling efficiency. A second method is the reduction of the radiolabel in the presence of the liposomes, resulting in the association of the label with the outside of the lipid bilayer. Studies have shown that instability may occur when applying this technique for neutral or positively charged liposomes. A third approach is to trap the radiolabel in the aqueous phase of preformed liposomes. This method has been proved useful in several studies. A chelator with high affinity for the radionuclide is entrapped during preparation, and the radionuclide is added to the liposomes before the experiment. These methods generally yield radiolabeled liposomes with good in vivo stability. The radiolabel can be chelated to a lipid–chelator conjugate in the lipid bilayer." @default.
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- W1533253593 date "2003-01-01" @default.
- W1533253593 modified "2023-09-23" @default.
- W1533253593 title "Radiolabeling of Liposomes for Scintigraphic Imaging" @default.
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- W1533253593 doi "https://doi.org/10.1016/s0076-6879(03)73015-8" @default.
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