FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1533301035> ?p ?o ?g. }

• W1533301035 abstract "Hematopoietic stem cell transplantation (HSCT) has the potential to cure a variety of malignant and nonmalignant diseases. Sources of hematopoietic stem cells for transplantation have expanded progressively since the beginning of the modern era of transplantation in the late 1960s. Although bone marrow was the main source of stem cells in the early years of transplantation, in the past 10 to 15 years peripheral blood has assumed increasing importance. The initial impetus for the use of PBSCs for transplantation was to be able to offer transplantation to patients who were not candidates for the use of bone marrow cells (tumor contamination of the marrow or those with hypocellular marrows). Subsequent studies demonstrated that PBSCs could be mobilized from the bone marrow with either hematopoietic growth factors (GM-CSF, G-CSF) or a combination of chemotherapy and growth factors, which increased the number of hematopoietic progenitors collected from the blood by 10to 1000fold compared with steady-state conditions. Umbilical cord blood represents the newest source of stem cells for transplantation. At now peripheral blood is the main source in the autologous setting. Within the allogeneic setting, multiple sources of stem cells are possible and include those derived from individuals related or unrelated to the patient. Hematopoietic progenitor cell (HPC) products contain hematopoietic stem and lineagecommitted progenitor cells capable of providing hematopoietic and immune reconstitution after myeloablative or reduced-intensity preparative regimens. HPCs administered intravenously migrate to the marrow, where they adhere, expand, selfrenew (stem cells only), and differentiate. The differentiated cells are released into the blood, restoring blood counts and immunity. The time from administration of HPCs to recovery of adequate or normal blood counts is variable. Recipients of peripheral blood stem cells recover counts faster than recipients of bone marrow. Cord blood tends to be the slowest to engraft. The minimum number of HPCs necessary for engraftment in a myeloablated recipient has not been established. Different products have widely different numbers of progenitors and stem cells. However, eligibility criteria for some protocols usually dictate a minimum number of cells to be collected and infused. Several methods are used to measure the number of cells in an HPC collection. Simple cell count may be adequate for many marrow collections. Most centers use flow cytometric enumeration of CD34+ cells for the majority of cellular products. The discovery of the CD34 antigen in the early 1980s revolutionized our understanding of hematopoiesis. Cells expressing CD34 are capable of reconstituting hematopoiesis in lethally irradiated animals and humans, indicating that the putative hematopoietic stem cell expresses CD34." @default.
• W1533301035 created "2016-06-24" @default.
• W1533301035 creator A5003382009 @default.
• W1533301035 creator A5066571049 @default.
• W1533301035 creator A5078285983 @default.
• W1533301035 date "2012-02-24" @default.
• W1533301035 modified "2023-09-23" @default.
• W1533301035 title "Sources of Hematopoietic Stem Cells" @default.
• W1533301035 cites W135272937 @default.
• W1533301035 cites W1481112340 @default.
• W1533301035 cites W1484959131 @default.
• W1533301035 cites W1497143314 @default.
• W1533301035 cites W149952967 @default.
• W1533301035 cites W1504660023 @default.
• W1533301035 cites W1506316893 @default.
• W1533301035 cites W1515967668 @default.
• W1533301035 cites W1548612891 @default.
• W1533301035 cites W1573785776 @default.
• W1533301035 cites W1591193872 @default.
• W1533301035 cites W160332237 @default.
• W1533301035 cites W1620751085 @default.
• W1533301035 cites W1693995824 @default.
• W1533301035 cites W1822308398 @default.
• W1533301035 cites W1834370350 @default.
• W1533301035 cites W1846458100 @default.
• W1533301035 cites W1853675239 @default.
• W1533301035 cites W1864374118 @default.
• W1533301035 cites W186453261 @default.
• W1533301035 cites W1879666912 @default.
• W1533301035 cites W1881943990 @default.
• W1533301035 cites W190201512 @default.
• W1533301035 cites W1958450672 @default.
• W1533301035 cites W1965613868 @default.
• W1533301035 cites W1967616608 @default.
• W1533301035 cites W1968849793 @default.
• W1533301035 cites W1970104570 @default.
• W1533301035 cites W1970730229 @default.
• W1533301035 cites W1970800877 @default.
• W1533301035 cites W1971160578 @default.
• W1533301035 cites W1971620157 @default.
• W1533301035 cites W197438979 @default.
• W1533301035 cites W1974394515 @default.
• W1533301035 cites W1975200389 @default.
• W1533301035 cites W1978039271 @default.
• W1533301035 cites W1978321902 @default.
• W1533301035 cites W1979602362 @default.
• W1533301035 cites W1980069749 @default.
• W1533301035 cites W1982750719 @default.
• W1533301035 cites W1983821870 @default.
• W1533301035 cites W1988068150 @default.
• W1533301035 cites W1990717544 @default.
• W1533301035 cites W1994719081 @default.
• W1533301035 cites W1996683133 @default.
• W1533301035 cites W1997427581 @default.
• W1533301035 cites W1998567244 @default.
• W1533301035 cites W2000944693 @default.
• W1533301035 cites W2002263898 @default.
• W1533301035 cites W2004060981 @default.
• W1533301035 cites W2004952507 @default.
• W1533301035 cites W2005688677 @default.
• W1533301035 cites W2007076411 @default.
• W1533301035 cites W2009197622 @default.
• W1533301035 cites W2009299193 @default.
• W1533301035 cites W2009382439 @default.
• W1533301035 cites W2010206621 @default.
• W1533301035 cites W2010365172 @default.
• W1533301035 cites W2010695172 @default.
• W1533301035 cites W2012088517 @default.
• W1533301035 cites W2013269422 @default.
• W1533301035 cites W2014576677 @default.
• W1533301035 cites W2014974498 @default.
• W1533301035 cites W2015352656 @default.
• W1533301035 cites W2018491765 @default.
• W1533301035 cites W2019381460 @default.
• W1533301035 cites W2021467368 @default.
• W1533301035 cites W2023512317 @default.
• W1533301035 cites W2024398591 @default.
• W1533301035 cites W2024835620 @default.
• W1533301035 cites W2025013227 @default.
• W1533301035 cites W2025122282 @default.
• W1533301035 cites W2027090443 @default.
• W1533301035 cites W2027936095 @default.
• W1533301035 cites W2027988268 @default.
• W1533301035 cites W2029491035 @default.
• W1533301035 cites W2032138029 @default.
• W1533301035 cites W2033563267 @default.
• W1533301035 cites W2034768868 @default.
• W1533301035 cites W2038413306 @default.
• W1533301035 cites W2039211544 @default.
• W1533301035 cites W2040356736 @default.
• W1533301035 cites W2042536188 @default.
• W1533301035 cites W2042650904 @default.
• W1533301035 cites W2044365441 @default.
• W1533301035 cites W2044744203 @default.
• W1533301035 cites W2045298969 @default.
• W1533301035 cites W2046542328 @default.
• W1533301035 cites W2051077249 @default.
• W1533301035 cites W2051415723 @default.
• W1533301035 cites W2051708180 @default.
• W1533301035 cites W2054426578 @default.

• next