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- W1533337187 abstract "The molecular basis for the absence of the CH1 domain in naturally occurring heavy-chain antibodies of the camelids was assessed by determining the entire Camelus dromedarius γ2a heavy-chain constant gene. The organization of the camel γ2a constant heavy-chain gene obtained from a liver genomic library appears to be typical of all other mammalian γ genes sequenced to date. It contains the switch, CH1, hinge, CH2, CH3, M1 and M2 exons. In contrast to the case in mouse and human heavy chain diseases, the camel γ2a gene shows no major structural defect, and its equivalent CH1 exon is intact. However, sequence analysis has revealed that the splicing site, immediately after the CH1 exon, is defective due to point mutations, especially the G+1 to A+1 transversion seems to be detrimental. It is concluded that the loss of the splice consensus signal is responsible for the removal of the entire CH1 domain in camel γ2a heavy-chain immunoglobulins. Additionally, a closer analysis of the hinge exon suggests the possible involvement of transposons in the genetic variation of mammalian Cγ hinges." @default.
- W1533337187 created "2016-06-24" @default.
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- W1533337187 date "1999-06-01" @default.
- W1533337187 modified "2023-09-30" @default.
- W1533337187 title "Loss of splice consensus signal is responsible for the removal of the entire CH1 domain of the functional camel IGG2A heavy-chain antibodies11This work was supported by the VLIR, VIB and FGWO." @default.
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- W1533337187 doi "https://doi.org/10.1016/s0161-5890(99)00067-x" @default.
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