Matches in SemOpenAlex for { <https://semopenalex.org/work/W1533358647> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W1533358647 endingPage "1579" @default.
- W1533358647 startingPage "1574" @default.
- W1533358647 abstract "Solid dispersions were prepared with a highly water-soluble medicine (oxprenolol hydrochloride (OXP)), water-insoluble ethylcellulose (EC) and four grades of water-soluble hydroxypropylcellulose (HPC) having different molecular weights. The effects of the composition ratio within the range of 5% of HPC and of the viscosity of HPC hydrogels on the release of OXP were studied. The bulk viscosity of HPC hydrogels was evaluated from the relationship between shear rate and shear stress. The microscopic viscosity was evaluated by the spin probe method of the electron spin resonance (ESR) technique.The release rate of OXP decreased with increasing HPC composition ratio and became almost constant at the HPC composition ratio of 3% and more. This result suggests that the release of OXP will occur through its diffusion into the swollen HPC gel phase formed in a solid dispersion at the HPC composition ratio of 3% and more. The bulk viscosity of HPC hydrogels markedly increased with increasing molecular weight of HPC, but there was little noticeable change in release rate and activation energy for the diffusion of OXP. This result can be explained by the fact that the microscopic viscosity was hardly affected by the molecular weight of HPC, suggesting that the resistance to diffusion of OXP into the swollen HPC gel phase in the solid dispersion was almost the same regardless of the moleclar weight of HPC." @default.
- W1533358647 created "2016-06-24" @default.
- W1533358647 creator A5012926846 @default.
- W1533358647 creator A5013308819 @default.
- W1533358647 creator A5032009845 @default.
- W1533358647 creator A5085310389 @default.
- W1533358647 date "1995-01-01" @default.
- W1533358647 modified "2023-10-16" @default.
- W1533358647 title "Application of the Solid Dispersion Method to the Controlled Release of Medicine. VIII. Medicine Release and Viscosity of the Hydrogel of a Water-Soluble Polymer in a Three-Component Solid Dispersion System." @default.
- W1533358647 cites W182402747 @default.
- W1533358647 doi "https://doi.org/10.1248/cpb.43.1574" @default.
- W1533358647 hasPublicationYear "1995" @default.
- W1533358647 type Work @default.
- W1533358647 sameAs 1533358647 @default.
- W1533358647 citedByCount "22" @default.
- W1533358647 countsByYear W15333586472012 @default.
- W1533358647 countsByYear W15333586472013 @default.
- W1533358647 countsByYear W15333586472015 @default.
- W1533358647 crossrefType "journal-article" @default.
- W1533358647 hasAuthorship W1533358647A5012926846 @default.
- W1533358647 hasAuthorship W1533358647A5013308819 @default.
- W1533358647 hasAuthorship W1533358647A5032009845 @default.
- W1533358647 hasAuthorship W1533358647A5085310389 @default.
- W1533358647 hasBestOaLocation W15333586471 @default.
- W1533358647 hasConcept C108586683 @default.
- W1533358647 hasConcept C113196181 @default.
- W1533358647 hasConcept C120665830 @default.
- W1533358647 hasConcept C121332964 @default.
- W1533358647 hasConcept C127172972 @default.
- W1533358647 hasConcept C127413603 @default.
- W1533358647 hasConcept C159985019 @default.
- W1533358647 hasConcept C165682214 @default.
- W1533358647 hasConcept C177562468 @default.
- W1533358647 hasConcept C178790620 @default.
- W1533358647 hasConcept C185592680 @default.
- W1533358647 hasConcept C188027245 @default.
- W1533358647 hasConcept C192562407 @default.
- W1533358647 hasConcept C42360764 @default.
- W1533358647 hasConcept C43617362 @default.
- W1533358647 hasConcept C521977710 @default.
- W1533358647 hasConcept C69357855 @default.
- W1533358647 hasConcept C97355855 @default.
- W1533358647 hasConceptScore W1533358647C108586683 @default.
- W1533358647 hasConceptScore W1533358647C113196181 @default.
- W1533358647 hasConceptScore W1533358647C120665830 @default.
- W1533358647 hasConceptScore W1533358647C121332964 @default.
- W1533358647 hasConceptScore W1533358647C127172972 @default.
- W1533358647 hasConceptScore W1533358647C127413603 @default.
- W1533358647 hasConceptScore W1533358647C159985019 @default.
- W1533358647 hasConceptScore W1533358647C165682214 @default.
- W1533358647 hasConceptScore W1533358647C177562468 @default.
- W1533358647 hasConceptScore W1533358647C178790620 @default.
- W1533358647 hasConceptScore W1533358647C185592680 @default.
- W1533358647 hasConceptScore W1533358647C188027245 @default.
- W1533358647 hasConceptScore W1533358647C192562407 @default.
- W1533358647 hasConceptScore W1533358647C42360764 @default.
- W1533358647 hasConceptScore W1533358647C43617362 @default.
- W1533358647 hasConceptScore W1533358647C521977710 @default.
- W1533358647 hasConceptScore W1533358647C69357855 @default.
- W1533358647 hasConceptScore W1533358647C97355855 @default.
- W1533358647 hasIssue "9" @default.
- W1533358647 hasLocation W15333586471 @default.
- W1533358647 hasOpenAccess W1533358647 @default.
- W1533358647 hasPrimaryLocation W15333586471 @default.
- W1533358647 hasRelatedWork W2014100643 @default.
- W1533358647 hasRelatedWork W2048316509 @default.
- W1533358647 hasRelatedWork W207779560 @default.
- W1533358647 hasRelatedWork W2079017388 @default.
- W1533358647 hasRelatedWork W2129731325 @default.
- W1533358647 hasRelatedWork W2325342448 @default.
- W1533358647 hasRelatedWork W2402567857 @default.
- W1533358647 hasRelatedWork W2990712642 @default.
- W1533358647 hasRelatedWork W3217475943 @default.
- W1533358647 hasRelatedWork W4296389124 @default.
- W1533358647 hasVolume "43" @default.
- W1533358647 isParatext "false" @default.
- W1533358647 isRetracted "false" @default.
- W1533358647 magId "1533358647" @default.
- W1533358647 workType "article" @default.