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- W1533408421 abstract "This chapter discusses gene rearrangements in thyroid cancer. Thyroid cancer is an epithelial neoplasm that is characterized by chromosomal rearrangements as a common genetic abnormality. This is unusual since large-scale rearrangements are typically found in lymphomas/leukemias and certain types of sarcomas, but not in epithelial tumors. One feature shared by thyroid cancer and other rearrangement-prone neoplasms is that all of them have ionizing radiation listed as a well-established etiologic factor. In thyroid tumors, rearranged in transformation/Papillary thyroid carcinomas (RET/PTC) and PAX8–PPARγ rearrangements are most common, and the frequency of both is significantly higher in tumors associated with radiation exposure. It points towards radiation as a possible factor directly involved in the induction of tumorigenic chromosomal rearrangements in human cells. However, overall, most thyroid tumors harboring these genetic aberrations arise in patients with no apparent history of irradiation. This raises the possibility of either unnoticed radiation exposure in many such individuals or the existence of other factors acting in a similar way to promote the rearrangement." @default.
- W1533408421 created "2016-06-24" @default.
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- W1533408421 date "2006-01-01" @default.
- W1533408421 modified "2023-09-23" @default.
- W1533408421 title "Chapter 1 Gene rearrangements in thyroid cancer" @default.
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- W1533408421 doi "https://doi.org/10.1016/s1569-2566(04)04001-3" @default.
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