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• W1533418542 abstract "It was demonstrated in 1963 that transplantable mouse and rat hepatomas synthesize and secrete into the blood a specific a-globulin of embryonic sera, «(-globulin (1, 6, 7). It was shown further that the same phenomenon of elaboration of embryonic serum a-globulin by hepatomas could be obtained by primary liver tumors of rats (20), mice (2, 23), and hu man beings (33, 34). An important aspect of the problem is the possibility of using a [-globulin appearance in the blood of patients for diag nosis of hepatomas in the clinic. The experimental data obtained in mice did not suggest such a possibility, since a rglobulin was revealed only in 25% of chemically induced primary liver tumors and this protein could be also demonstrated by liver regeneration. The detection of a {-globulin in clinical cases might, however, be of certain value in differential diagnosis of hepatocellular carcinoma. Thus, Tatarinov (33), who was the first to find this globulin in cases of human hepatoma, was unable to detect it either in cases of cholangioma and secondary localization of other tumors in liver or in noncancerous diseases accom panied by liver regeneration, such as cirrhosis and hepatitis. He regularly revealed «(-globulin in the blood of patients with hepatocellular liver cancer. Immunochemical diagnosis, as dis tinct from clinical, was in full coincidence with autopsy data. By 1966 Tatarinov et al. (33, 34, 36, 37) described 6 cases of arglobulin appearance in primary hepatomas on the back ground of numerous negative controls. One additional case was described by Czech investigators (25). This suggests that the arglobulin test is both more regular and more specific in hu man hepatomas than in experimentally induced tumors, at least in mice. The main findings reported by Tatarinov have been con firmed and extended by 2 separate groups: ours, in collabora tion with the Institute of Experimental and Clinical Oncology of the USSR Academy of Medical Sciences (3, 10, 36), and by Grabar's group in Villejuif and Dakar (38). The results" @default.
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• W1533418542 date "1968-07-01" @default.
• W1533418542 modified "2023-09-23" @default.
• W1533418542 title "Production of embryonal serum alpha-globulin by hepatomas: review of experimental and clinical data." @default.
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