FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1533452775> ?p ?o ?g. }

• W1533452775 endingPage "480" @default.
• W1533452775 startingPage "471" @default.
• W1533452775 abstract "We retrospectively examined the association of polymorphisms in the CYP3A, CYP2J2, CYP2C8, and ABCB1 genes with pharmacokinetic (PKs) and pharmacodynamic (PDs) parameters of tacrolimus in 103 renal transplant recipients for a period of 1 year. CYP3A5 expressers had lower predose concentrations (C(0) )/dose and higher dose requirements than nonexpressers throughout the study. Among CYP3A5*1 carriers, those also carrying the CYP3A4*1B allele showed the lowest C(0) /dose, as compared with CYP3A4*1/CYP3A5*3 carriers (54.28±26.45, 59.12±24.00, 62.43±41.12, and 57.01±17.34 vs. 112.37± 76.60, 123.21±59.57, 163.34±76.23, and 183.07±107.82 at 1 week, 1 month, 5 months, and 1 year after transplantation). In addition, CYP3A4*1B/CYP3A5*1 carriers showed significantly lower dose-corrected exposure than CYP3A4*1/CYP3A5*1 carriers 1 year after transplantation (57.01±17.34 vs. 100.09±24.78; P=0.016). Only the ABCB1 TGC (3435-2677-1236) haplotype showed a consistent association with PDs (nephrotoxicity; OR=4.73; CI: 1.3-16.7; P=0.02). Our findings indicate that the CYP3A4*1B-CYP3A5*1 haplotype may have a more profound impact in tacrolimus PKs than the CYP3A5*1 allele. This study does not support a critical role of the CYP450 or ABCB1 single nucleotide polymorphisms in the occurrence of toxicity or acute rejection in renal transplant recipients treated with tacrolimus." @default.
• W1533452775 created "2016-06-24" @default.
• W1533452775 creator A5017003826 @default.
• W1533452775 creator A5021818227 @default.
• W1533452775 creator A5023810691 @default.
• W1533452775 creator A5031804025 @default.
• W1533452775 creator A5048631714 @default.
• W1533452775 creator A5089437659 @default.
• W1533452775 date "2012-02-28" @default.
• W1533452775 modified "2023-10-13" @default.
• W1533452775 title "Impact of genetic polymorphisms on tacrolimus pharmacokinetics and the clinical outcome of renal transplantation" @default.
• W1533452775 cites W1558311166 @default.
• W1533452775 cites W1894997478 @default.
• W1533452775 cites W1908242974 @default.
• W1533452775 cites W1916760512 @default.
• W1533452775 cites W1969838970 @default.
• W1533452775 cites W1973471615 @default.
• W1533452775 cites W1979150683 @default.
• W1533452775 cites W1980084521 @default.
• W1533452775 cites W1991471509 @default.
• W1533452775 cites W1992188999 @default.
• W1533452775 cites W1992303064 @default.
• W1533452775 cites W1993182297 @default.
• W1533452775 cites W1994554038 @default.
• W1533452775 cites W1997969281 @default.
• W1533452775 cites W2002553095 @default.
• W1533452775 cites W2003099643 @default.
• W1533452775 cites W2004159306 @default.
• W1533452775 cites W2004411083 @default.
• W1533452775 cites W2004718408 @default.
• W1533452775 cites W2024131514 @default.
• W1533452775 cites W2027774666 @default.
• W1533452775 cites W2032584539 @default.
• W1533452775 cites W2033833126 @default.
• W1533452775 cites W2034728660 @default.
• W1533452775 cites W2038803245 @default.
• W1533452775 cites W2038989721 @default.
• W1533452775 cites W2049268060 @default.
• W1533452775 cites W2064001298 @default.
• W1533452775 cites W2071659692 @default.
• W1533452775 cites W2076454486 @default.
• W1533452775 cites W2077109037 @default.
• W1533452775 cites W2083650072 @default.
• W1533452775 cites W2087604902 @default.
• W1533452775 cites W2088250393 @default.
• W1533452775 cites W2094826866 @default.
• W1533452775 cites W2105902511 @default.
• W1533452775 cites W2106004363 @default.
• W1533452775 cites W2120817045 @default.
• W1533452775 cites W2121987020 @default.
• W1533452775 cites W2126262050 @default.
• W1533452775 cites W2146837949 @default.
• W1533452775 cites W2152583392 @default.
• W1533452775 cites W2160859576 @default.
• W1533452775 cites W2330615898 @default.
• W1533452775 cites W2791969457 @default.
• W1533452775 cites W4211179245 @default.
• W1533452775 doi "https://doi.org/10.1111/j.1432-2277.2012.01446.x" @default.
• W1533452775 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22369694" @default.
• W1533452775 hasPublicationYear "2012" @default.
• W1533452775 type Work @default.
• W1533452775 sameAs 1533452775 @default.
• W1533452775 citedByCount "77" @default.
• W1533452775 countsByYear W15334527752012 @default.
• W1533452775 countsByYear W15334527752013 @default.
• W1533452775 countsByYear W15334527752014 @default.
• W1533452775 countsByYear W15334527752015 @default.
• W1533452775 countsByYear W15334527752016 @default.
• W1533452775 countsByYear W15334527752017 @default.
• W1533452775 countsByYear W15334527752018 @default.
• W1533452775 countsByYear W15334527752019 @default.
• W1533452775 countsByYear W15334527752020 @default.
• W1533452775 countsByYear W15334527752021 @default.
• W1533452775 countsByYear W15334527752022 @default.
• W1533452775 countsByYear W15334527752023 @default.
• W1533452775 crossrefType "journal-article" @default.
• W1533452775 hasAuthorship W1533452775A5017003826 @default.
• W1533452775 hasAuthorship W1533452775A5021818227 @default.
• W1533452775 hasAuthorship W1533452775A5023810691 @default.
• W1533452775 hasAuthorship W1533452775A5031804025 @default.
• W1533452775 hasAuthorship W1533452775A5048631714 @default.
• W1533452775 hasAuthorship W1533452775A5089437659 @default.
• W1533452775 hasConcept C104317684 @default.
• W1533452775 hasConcept C109650736 @default.
• W1533452775 hasConcept C112705442 @default.
• W1533452775 hasConcept C126189478 @default.
• W1533452775 hasConcept C126322002 @default.
• W1533452775 hasConcept C135763542 @default.
• W1533452775 hasConcept C2909675724 @default.
• W1533452775 hasConcept C2911091166 @default.
• W1533452775 hasConcept C29730261 @default.
• W1533452775 hasConcept C526171541 @default.
• W1533452775 hasConcept C54355233 @default.
• W1533452775 hasConcept C62231903 @default.
• W1533452775 hasConcept C71924100 @default.
• W1533452775 hasConcept C86803240 @default.
• W1533452775 hasConcept C90924648 @default.
• W1533452775 hasConcept C92137452 @default.

• next