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• W1533479685 abstract "Theophylline is commonly used in the treatment of obstructive airway diseases. The identification and functional characterization of different phosphodiesterase (PDE) isoenzymes has led to the development of various isoenzyme‐selective inhibitors as potential anti‐asthma drugs. Considering the distribution of isoenzymes in target tissues, with high activity of PDE3 and PDE4 in airway smooth muscle and inflammatory cells, selective inhibitors of these isoenzymes may add to the therapy of chronic airflow obstruction. However, initial data from clinical trials with selective PDE3 and PDE4 inhibitors have been somewhat disappointing and have tempered the expectations considerably since these drugs had limited efficacy and their use was clinically limited through side effects. The improved understanding of the molecular biology of PDEs enabled the synthesis of novel drugs with an improved risk/benefit ratio. These ‘second generation’ selective drugs have produced more promising clinical results not only for the treatment of bronchial asthma but also for the treatment of chronic obstructive pulmonary disease." @default.
• W1533479685 created "2016-06-24" @default.
• W1533479685 creator A5000900747 @default.
• W1533479685 creator A5047388743 @default.
• W1533479685 creator A5053448019 @default.
• W1533479685 date "1999-06-01" @default.
• W1533479685 modified "2023-10-16" @default.
• W1533479685 title "Selective phosphodiesterase inhibitors for the treatment of bronchial asthma and chronic obstructive pulmonary disease" @default.
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• W1533479685 doi "https://doi.org/10.1046/j.1365-2222.1999.00018.x" @default.
• W1533479685 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10421832" @default.
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