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- W1533500268 abstract "Recent evidence suggests that Indo is more effective when used earlyto treat PDA in VLBW.We have cared for some VLBW infants who were given Proph Indo IV within the first 10 hours of life, before there were any signs of PDA.In order to evaluate the results of such practice,we reviewed the charts of the 76 infants < 1500g who survived more than 24 hours during the past year.Twenty received Proph Indo(.2mg/kg q 8 h)and 56 did not(Non Proph Indo group).The mean birth weight,gest.age,sex ratio and Apgar scores were comparable.In Proph Indo group,17(85%) had HMD;only 1 (5%)had PDA and 6(30%)died.In the Non Proph Indo group,25(45%) had HMD,24(43%)developed PDA,and 14(25%)died.The results for infants with HMD are shown in the Table. There were no significant complications with Proph Indo.In HMD Non Proph Indo,17(68%)received Indo for PDA,6(35%)requiered more than 1 series and 2 still had symptoms at death.Two had severe BPD and died.One underwent surgery after 3 series of Indo. We conclude that Proph Indo is effective in VLBW infants to prevent the occurrence of PDA.In VLBW infants with HMD the use of Proph Indo seems associated with less mortality and morbidity." @default.
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- W1533500268 date "1984-04-01" @default.
- W1533500268 modified "2023-09-26" @default.
- W1533500268 title "SHOULD PROPHYLACTIC INDOMETHACIN (PROPH INDO)BE USED IN VLBW INFANTS WITH HYALINE MEMBRANE DISEASE(HMD)?" @default.
- W1533500268 doi "https://doi.org/10.1203/00006450-198404001-01528" @default.
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