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• W1533572010 abstract "Over the past two decades, numerous compounds using radiolabeled antibodies or their fragments have been investigated for diagnostic imaging purposes. Satumomab is a murine monoclonal antibody of the immunoglobulin subclass IgG that binds to the tumor-associated glycoprotein (TAG) 72 antigen, a cell surface antigen expressed at high levels on nearly all colorectal and ovarian adenocarcinomas. Arcitumomab is an IgG1 (K class antibody) Fab fragment specific for carcinoembryonic antigen (CEA) expressed on the cell surface of numerous tumors, particularly those of the gastrointestinal tract. Capromab is a murine monoclonal antibody of the IgG1, kappa subclass (IgG1κ), which is directed against a glycoprotein known as prostate specific membrane antigen (PSMA) that is expressed by prostate epithelium. For a variety of reasons, these agents have had minimal use and only one is available in the United States, indium-111 labeled capromab for prostate carcinoma. Imicromab is a Fab fragment of a murine monoclonal antibody (IgG2aκ) that binds to the heavy chain of human myosin, an intracellular protein present in both cardiac and skeletal muscle cells. It was anticipated that radiolabeled imicromab could potentially be a useful noninvasive diagnostic tool to quantify myocardial necrosis and to assess prognosis in ischemic, inflammatory, and toxic myocardial disease, but clinical interest in this agent waned and it was taken off the market just a few years after its introduction. In vitro labeled autologous labeled leukocyte imaging is the radionuclide “gold standard” for imaging most infections in the immunocompetent population. There are significant limitations to this procedure and considerable effort has been devoted to developing in vivo methods of labeling leukocytes, including antigranulocyte antibodies and antibody fragments. Besilesomab, a murine monoclonal antibody of the IgG1 kappa isotype binds to antigenic structures shared by the tumor marker CEA and the surface glycoprotein, nonspecific cross-reacting antigen-95 (NCA-95), an epitope expressed on the cell membrane of granulocytes and granulocyte precursors. A significant disadvantage of 99mTc-besilesomab is the high incidence of dose-dependent HAMA response, which ranges from less than 5% in patients receiving a single dose of 125 mg of antibody to more than 30% in patients receiving repeated injections. Patients should be screened for HAMA prior to besilesomab administration and a positive test is a contraindication. Repeat administration is not recommended. Fanolesomab is an M class immunoglobulin that exhibits a high affinity for the carbohydrate moiety 3-fucosyl-N-acetyl lactosamine contained in the CD15 antigen expressed on human leukocytes. Approximately 18 months after its introduction 99mTc-fanolesomab was withdrawn from the market following reports of serious and life-threatening cardiopulmonary events, including two fatalities, shortly after administration. Sulesomab is a fragment antigen binding (Fab') portion of a murine monoclonal antibody of the IgG1 class that binds to normal cross-reactive antigen-90, which is present on leukocytes, the macrophage–monocyte cell lineage, in normal colonic mucosa and in colonic adenocarcinoma. Although early investigations suggested that uptake mechanisms include binding both to circulating neutrophils that subsequently migrate to foci of infection and to leukocytes already present at the site of infection, more recent data indicate that sulesomab is cleared into infection nonspecifically through increased capillary membrane permeability. Unfavorable imaging characteristics, concerns about HAMA, increased sophistication of morphologic imaging tests, and the rapid proliferation of clinical FDG-PET all have impacted negatively on the use of radiolabeled antibodies for diagnostic imaging. The role of this once promising technique now faces an uncertain future." @default.
• W1533572010 created "2016-06-24" @default.
• W1533572010 creator A5090461114 @default.
• W1533572010 date "2014-08-12" @default.
• W1533572010 modified "2023-09-26" @default.
• W1533572010 title "Radiolabeled Antibodies for Diagnostic Imaging" @default.
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• W1533572010 doi "https://doi.org/10.1002/9783527682423.ch76" @default.
• W1533572010 hasPublicationYear "2014" @default.
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