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- W1533915019 abstract "Summary The metabolism of polycyclic aromatic hydrocarbons to water-soluble and organic-soluble products was studied in cultures of cells under conditions for their malignant transformation. The amount of conversion to water-soluble metabolites was proportional to the cell number and increased with time; it was also proportional to the amount of hydrocarbon up to 103 to 104 eemoles/3 × 106 mouse cells. A further increase in quantity of hydrocarbon did not significantly alter the rate of production of water-soluble metabolites. The metabolism of a series of five polycyclic hydrocarbons was varied. The greatest production of water-soluble metabolites was from 3,4-benzopyrene and the lowest was from 1,2,5,6-dibenzanthracene. A close relationship was found between the susceptibility of cells from different rodents to the cytotoxic effect of 3-methylcholanthrene and the amount of water-soluble metabolites produced. The major metabolites from 1,2,5,6-dibenzanthracene were dihydrodiols; from 9,10-dimethyl-1,2-benzanthracene, dihydrodiols, and hydroxymethyl derivatives were highest; while with both the compounds, the phenols were produced in lower quantity." @default.
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- W1533915019 date "1971-12-01" @default.
- W1533915019 modified "2023-09-23" @default.
- W1533915019 title "Metabolism of polycyclic aromatic hydrocarbons in cell cultuires." @default.
- W1533915019 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4107644" @default.
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