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- W1533993249 abstract "Publisher Summary In psychopharmacology, it is common to employ drugs known to interact with a neurotransmitter system as a tool for studying the mechanism of action of psychotropic drugs. This approach has led to considerable progress in understanding the mechanism of action of drugs, but it must be applied with caution. The selectivity of drugs exerting a given biochemical effect must always be established under the same precise experimental conditions because it is very difficult to extrapolate across doses, routes of administration, times after dosing, animal species, and brain regions. In a drug interaction study, comparisons must be made at equal brain-or brain area-concentrations to make sure no metabolic interaction has occurred. In fact, one drug may change the effect of another by affecting its disposition as regards organ distribution, protein binding, and formation of active metabolites. Moreover, the specificity frequently lies within a narrow dose range, outside which interactions may occur with other chemical mediators. Interference with a chemical mediator in a certain area is not necessarily the same in all brain areas. The links between various chemical mediators may differ widely depending on the brain structure considered. This chapter gives some examples about the use of drugs in studying monoamine functions, with the aim of cautioning against oversimplified conclusions from pharmacological experiments. Particular attention is paid to drugs acting on uptake and release of monoamines and to drugs acting on monoamine receptors." @default.
- W1533993249 created "2016-06-24" @default.
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- W1533993249 date "1988-01-01" @default.
- W1533993249 modified "2023-10-16" @default.
- W1533993249 title "Critical Notes on The Specificity of Drugs in The Study of Metabolism and Functions of Brain Monoamines" @default.
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- W1533993249 doi "https://doi.org/10.1016/s0074-7742(08)60089-6" @default.
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