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- W1534033384 abstract "Chromophore-assisted light inactivation (CALI) is developed as a means of targeted inactivation of proteins to generate a protein loss of function at the time of light excitation. Based on the twentieth anniversary of its invention, it is timely to review the development of CALI technology, its use to ascribe in situ function, and the future of its potential application. The development of CALI was derived from two ideas: (1) laser ablation of whole cells in vitro and in simple organisms such as grasshopper and (ii) the promise of monoclonal antibody technology to deliver highly specific inhibitors of protein function had not been realized. Combining these ideas led the author to consider that laser energy might be targeted to damage specific proteins via antibodies using a dye that would absorb wavelengths of light not readily absorbed by cells or tissue. The earliest CALI-based studies were performed using grasshopper embryos in vivo. Controlled Vocabulary Terms laser beam effects" @default.
- W1534033384 created "2016-06-24" @default.
- W1534033384 creator A5017883303 @default.
- W1534033384 date "2010-10-04" @default.
- W1534033384 modified "2023-10-17" @default.
- W1534033384 title "Chromophore-Assisted Light Inactivation: A Twenty-Year Retrospective" @default.
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- W1534033384 doi "https://doi.org/10.1002/9783527632053.ch4" @default.
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