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- W1534072142 abstract "Fab fragments of Tc-99m labeled antibodies directed against the heavy chain of human cardiac myosin (anti-myosin, AM) have been used for the location and sizing of acute myocardial necrosis in man. To determine if the choice of radiolabel altered the concentration of antibody in the zone of necrosis, a series of 20 patients (10 of each group) with infarcts of comparable size and location were evaluated. Regions-of-interest were drawn on the anterior view and the count density in the zone of necrosis compared to that in lungs, liver, blood pool and spleen. Images were recorded with a large field-of-view camera with a dedicated computer using a low energy collimator for Tc-99m and medium energy collimator for In-111. The count density ratios are presented in this paper. In this paper the data demonstrate the improvement in MI contrast with In-111 Fab AM. In addition, the relative reduction of activity in the liver and spleen make the detection of MI in the inferior and apical surfaces of the heart easier. In conclusion, In-111 Fab AM appears preferable to Tc-99m Fab AM for the detection of acute myocardial necrosis in man." @default.
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- W1534072142 date "1985-05-01" @default.
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- W1534072142 title "Comparison of image characteristics of In-111-antimyosin and Tc-99m antimyosin in patients with acute myocardial infarction" @default.
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