FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1534075308> ?p ?o ?g. }

• W1534075308 endingPage "1181" @default.
• W1534075308 startingPage "1168" @default.
• W1534075308 abstract "PA3535 (EprS), an autotransporter (AT) protein of Pseudomonas aeruginosa, is predicted to contain a serine protease motif. The eprS encodes a 104.5 kDa protein with a 30-amino-acid-long signal peptide, a 51.2 kDa amino-terminal secreted passenger domain and a 50.1 kDa carboxyl-terminal outer membrane channel formed translocator. Although the majority of AT proteins have been reported to be virulence factors, little is known about the functions of EprS in the pathogenicity of P. aeruginosa. In this study, we performed functional analyses of recombinant EprS secreted by Escherichia coli. The proteolytic activity of EprS was markedly decreased by changing Ser to Ala at position 308 or by serine protease inhibitors. EprS preferred to cleave substrates that terminated with arginine or lysine residues. Thus, these results indicate that EprS, a serine protease, displays the substrate specificity, cleaving after basic residues. We demonstrated that EprS activates NF-κB-driven promoters through protease-activated receptor (PAR)-1, -2 or -4 and induces IL-8 production through PAR-2 in a human bronchiole epithelial cell line. Moreover, EprS cleaved the peptides corresponding to the tethered ligand region of PAR-1, -2 and -4 at a specific site with exposure oftheir tethered ligands. Collectively, these results suggest that EprS activates host inflammatory responses through PARs." @default.
• W1534075308 created "2016-06-24" @default.
• W1534075308 creator A5054949063 @default.
• W1534075308 creator A5056178993 @default.
• W1534075308 creator A5057053876 @default.
• W1534075308 creator A5080408351 @default.
• W1534075308 creator A5083401692 @default.
• W1534075308 date "2013-01-28" @default.
• W1534075308 modified "2023-09-23" @default.
• W1534075308 title "EprS, an autotransporter protein of<i>Pseudomonas aeruginosa</i>, possessing serine protease activity induces inflammatory responses through protease-activated receptors" @default.
• W1534075308 cites W12119413 @default.
• W1534075308 cites W1484675846 @default.
• W1534075308 cites W1486946238 @default.
• W1534075308 cites W1598859659 @default.
• W1534075308 cites W1623022149 @default.
• W1534075308 cites W1647699403 @default.
• W1534075308 cites W1833330542 @default.
• W1534075308 cites W1889671843 @default.
• W1534075308 cites W1908391556 @default.
• W1534075308 cites W1963938486 @default.
• W1534075308 cites W1964603015 @default.
• W1534075308 cites W1973516496 @default.
• W1534075308 cites W1986727056 @default.
• W1534075308 cites W1994634407 @default.
• W1534075308 cites W1999564888 @default.
• W1534075308 cites W2003046928 @default.
• W1534075308 cites W2005058090 @default.
• W1534075308 cites W2005221143 @default.
• W1534075308 cites W2006421939 @default.
• W1534075308 cites W2008407831 @default.
• W1534075308 cites W2008627610 @default.
• W1534075308 cites W2013106856 @default.
• W1534075308 cites W2015718294 @default.
• W1534075308 cites W2016957221 @default.
• W1534075308 cites W2018568586 @default.
• W1534075308 cites W2022101101 @default.
• W1534075308 cites W2024792147 @default.
• W1534075308 cites W2026545058 @default.
• W1534075308 cites W2029835409 @default.
• W1534075308 cites W2030201584 @default.
• W1534075308 cites W2034959804 @default.
• W1534075308 cites W2044357500 @default.
• W1534075308 cites W2046608295 @default.
• W1534075308 cites W2048989975 @default.
• W1534075308 cites W2050269111 @default.
• W1534075308 cites W2051975001 @default.
• W1534075308 cites W2058401381 @default.
• W1534075308 cites W2059027572 @default.
• W1534075308 cites W2059775775 @default.
• W1534075308 cites W2064296383 @default.
• W1534075308 cites W2071833026 @default.
• W1534075308 cites W2080560063 @default.
• W1534075308 cites W2083917706 @default.
• W1534075308 cites W2085176272 @default.
• W1534075308 cites W2092631613 @default.
• W1534075308 cites W2098516009 @default.
• W1534075308 cites W2099820072 @default.
• W1534075308 cites W2100325336 @default.
• W1534075308 cites W2109951903 @default.
• W1534075308 cites W2111069670 @default.
• W1534075308 cites W2112536267 @default.
• W1534075308 cites W2114640540 @default.
• W1534075308 cites W2126130975 @default.
• W1534075308 cites W2127539199 @default.
• W1534075308 cites W2134066586 @default.
• W1534075308 cites W2135838357 @default.
• W1534075308 cites W2137691973 @default.
• W1534075308 cites W2139411571 @default.
• W1534075308 cites W2142814460 @default.
• W1534075308 cites W2149163736 @default.
• W1534075308 cites W2149353640 @default.
• W1534075308 cites W2155208387 @default.
• W1534075308 cites W2156801648 @default.
• W1534075308 cites W2157252661 @default.
• W1534075308 cites W2163250267 @default.
• W1534075308 cites W2163351388 @default.
• W1534075308 cites W2165320241 @default.
• W1534075308 cites W2166412853 @default.
• W1534075308 cites W2168695460 @default.
• W1534075308 cites W2168755417 @default.
• W1534075308 doi "https://doi.org/10.1111/cmi.12106" @default.
• W1534075308 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23311922" @default.
• W1534075308 hasPublicationYear "2013" @default.
• W1534075308 type Work @default.
• W1534075308 sameAs 1534075308 @default.
• W1534075308 citedByCount "21" @default.
• W1534075308 countsByYear W15340753082013 @default.
• W1534075308 countsByYear W15340753082014 @default.
• W1534075308 countsByYear W15340753082015 @default.
• W1534075308 countsByYear W15340753082016 @default.
• W1534075308 countsByYear W15340753082018 @default.
• W1534075308 countsByYear W15340753082019 @default.
• W1534075308 countsByYear W15340753082020 @default.
• W1534075308 countsByYear W15340753082021 @default.
• W1534075308 countsByYear W15340753082022 @default.
• W1534075308 countsByYear W15340753082023 @default.
• W1534075308 crossrefType "journal-article" @default.
• W1534075308 hasAuthorship W1534075308A5054949063 @default.

• next