FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1534194237> ?p ?o ?g. }

• W1534194237 endingPage "23923" @default.
• W1534194237 startingPage "23915" @default.
• W1534194237 abstract "GATA-1 is a lineage-restricted transcription factor. Virtually all erythroid-expressed genes contain GATA recognition sites in their regulatory elements. Cotransfection/transactivation assays have revealed that, although GATA-1 as the only cell-restricted transcription factor is sufficient to activate some of the erythroid-specific promoters, not all such promoters are responsive, suggesting a requirement for cooperation with other factors. To study the interaction of GATA-1 with other transactivators, we analyzed sequence motifs of the human gamma-globin promoter as response system by in vitro transcription and by transfections into erythroid K562 cells or into heterologous Drosophila SL2 cells. GATA-1 alone did not activate the promoter. However, GATA-1 exerted an effect in concert with the ubiquitous transactivator Sp1. Depending on the factor concentrations and the sequence context of the cognate binding sites, this interaction could result in synergistic transcriptional activation or in interference. GATA-1 and Sp1 did not cooperate in DNA binding when tested in vitro. This suggests that the functional cooperation is mediated by protein interactions with additional factor(s) which transmit the activator signal. The Sp1-binding CCACCC motif was found to be critical for high activity of the gamma-globin promoter. This site overlaps with a recognition sequence for members of the NFI/CTF family. NFI did not transactivate, but it interfered with Sp1-mediated stimulation and hence with Sp1/GATA-1 cooperation. These data, together with phylogenetic evidence, suggest that the CCACCC region is likely to represent a regulatory switch element." @default.
• W1534194237 created "2016-06-24" @default.
• W1534194237 creator A5049434800 @default.
• W1534194237 creator A5087776077 @default.
• W1534194237 creator A5089012338 @default.
• W1534194237 date "1993-11-01" @default.
• W1534194237 modified "2023-10-18" @default.
• W1534194237 title "Cooperation of GATA-1 and Sp1 can result in synergistic transcriptional activation or interference." @default.
• W1534194237 cites W1214455787 @default.
• W1534194237 cites W1897425192 @default.
• W1534194237 cites W1970234384 @default.
• W1534194237 cites W1978713358 @default.
• W1534194237 cites W1979704489 @default.
• W1534194237 cites W1982695907 @default.
• W1534194237 cites W1983512144 @default.
• W1534194237 cites W1986128871 @default.
• W1534194237 cites W1987124912 @default.
• W1534194237 cites W1993243592 @default.
• W1534194237 cites W2001772277 @default.
• W1534194237 cites W2008494281 @default.
• W1534194237 cites W2013803304 @default.
• W1534194237 cites W2018458653 @default.
• W1534194237 cites W2019257250 @default.
• W1534194237 cites W2025847301 @default.
• W1534194237 cites W2027216583 @default.
• W1534194237 cites W2033823242 @default.
• W1534194237 cites W2034277598 @default.
• W1534194237 cites W2037653294 @default.
• W1534194237 cites W2043672573 @default.
• W1534194237 cites W2054254765 @default.
• W1534194237 cites W2055568103 @default.
• W1534194237 cites W205934865 @default.
• W1534194237 cites W2060238756 @default.
• W1534194237 cites W2074378056 @default.
• W1534194237 cites W2085206941 @default.
• W1534194237 cites W2086548325 @default.
• W1534194237 cites W2092668266 @default.
• W1534194237 cites W2093675852 @default.
• W1534194237 cites W2105601424 @default.
• W1534194237 cites W2107620873 @default.
• W1534194237 cites W2109664605 @default.
• W1534194237 cites W2130487814 @default.
• W1534194237 cites W2137677335 @default.
• W1534194237 cites W2141395444 @default.
• W1534194237 cites W2150277522 @default.
• W1534194237 cites W215728627 @default.
• W1534194237 cites W2165135585 @default.
• W1534194237 cites W2169578753 @default.
• W1534194237 cites W4241680138 @default.
• W1534194237 doi "https://doi.org/10.1016/s0021-9258(20)80472-4" @default.
• W1534194237 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8226931" @default.
• W1534194237 hasPublicationYear "1993" @default.
• W1534194237 type Work @default.
• W1534194237 sameAs 1534194237 @default.
• W1534194237 citedByCount "114" @default.
• W1534194237 countsByYear W15341942372013 @default.
• W1534194237 countsByYear W15341942372015 @default.
• W1534194237 countsByYear W15341942372017 @default.
• W1534194237 countsByYear W15341942372020 @default.
• W1534194237 countsByYear W15341942372021 @default.
• W1534194237 crossrefType "journal-article" @default.
• W1534194237 hasAuthorship W1534194237A5049434800 @default.
• W1534194237 hasAuthorship W1534194237A5087776077 @default.
• W1534194237 hasAuthorship W1534194237A5089012338 @default.
• W1534194237 hasBestOaLocation W15341942371 @default.
• W1534194237 hasConcept C104317684 @default.
• W1534194237 hasConcept C127162648 @default.
• W1534194237 hasConcept C166703698 @default.
• W1534194237 hasConcept C185592680 @default.
• W1534194237 hasConcept C31258907 @default.
• W1534194237 hasConcept C32022120 @default.
• W1534194237 hasConcept C41008148 @default.
• W1534194237 hasConcept C54355233 @default.
• W1534194237 hasConcept C67705224 @default.
• W1534194237 hasConcept C70721500 @default.
• W1534194237 hasConcept C86803240 @default.
• W1534194237 hasConcept C95444343 @default.
• W1534194237 hasConceptScore W1534194237C104317684 @default.
• W1534194237 hasConceptScore W1534194237C127162648 @default.
• W1534194237 hasConceptScore W1534194237C166703698 @default.
• W1534194237 hasConceptScore W1534194237C185592680 @default.
• W1534194237 hasConceptScore W1534194237C31258907 @default.
• W1534194237 hasConceptScore W1534194237C32022120 @default.
• W1534194237 hasConceptScore W1534194237C41008148 @default.
• W1534194237 hasConceptScore W1534194237C54355233 @default.
• W1534194237 hasConceptScore W1534194237C67705224 @default.
• W1534194237 hasConceptScore W1534194237C70721500 @default.
• W1534194237 hasConceptScore W1534194237C86803240 @default.
• W1534194237 hasConceptScore W1534194237C95444343 @default.
• W1534194237 hasIssue "32" @default.
• W1534194237 hasLocation W15341942371 @default.
• W1534194237 hasOpenAccess W1534194237 @default.
• W1534194237 hasPrimaryLocation W15341942371 @default.
• W1534194237 hasRelatedWork W1920751942 @default.
• W1534194237 hasRelatedWork W1991523530 @default.
• W1534194237 hasRelatedWork W2002128513 @default.
• W1534194237 hasRelatedWork W2020824267 @default.
• W1534194237 hasRelatedWork W2031436818 @default.

• next