Matches in SemOpenAlex for { <https://semopenalex.org/work/W1534283717> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W1534283717 abstract "Combined BRAF and MEK inhibition has improved patient outcomes beyond single agent BRAF inhibition in BRAF-mutant metastatic melanoma, however 25% of patients do not have a RECIST-response and 30% progress within six months. Analysis of melanoma progressing metastases from combination-treated patients reveals that early resistance via the MAP kinase pathway is more common than that observed with single agent BRAF inhibition, which raises the questions of whether even stronger MAP kinase pathway inhibition would be of benefit to patients, and whether this is achievable therapeutically. However, the combination of MAP kinase inhibitors with immunotherapy may be a more effective strategy. Preliminary results in human tissues suggest that the presence of tumor-infiltrating lymphocytes and tumor-cell PDL1 expression may assist in patient selection for such a strategy. Early-during treatment responding metastases from combined BRAF and MEK inhibition-treated patients demonstrate similar levels of tumor-infiltrating lymphocytes as observed with single agent BRAF inhibition, suggesting that MEK inhibitors may not negatively impact the immunogenicity of targeted therapy early-on, and supports the concept that concurrent targeted- and immuno-therapy strategies may provide a greater opportunity for disease control than in sequence. Citation Format: Georgina V. Long. Combined targeted therapies, where to next. [abstract]. In: Proceedings of the AACR Special Conference on Advances in Melanoma: From Biology to Therapy; Sep 20-23, 2014; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(14 Suppl):Abstract nr IA30." @default.
- W1534283717 created "2016-06-24" @default.
- W1534283717 creator A5070576000 @default.
- W1534283717 date "2015-07-15" @default.
- W1534283717 modified "2023-09-26" @default.
- W1534283717 title "Abstract IA30: Combined targeted therapies, where to next" @default.
- W1534283717 doi "https://doi.org/10.1158/1538-7445.mel2014-ia30" @default.
- W1534283717 hasPublicationYear "2015" @default.
- W1534283717 type Work @default.
- W1534283717 sameAs 1534283717 @default.
- W1534283717 citedByCount "0" @default.
- W1534283717 crossrefType "proceedings-article" @default.
- W1534283717 hasAuthorship W1534283717A5070576000 @default.
- W1534283717 hasConcept C121608353 @default.
- W1534283717 hasConcept C126322002 @default.
- W1534283717 hasConcept C143998085 @default.
- W1534283717 hasConcept C184235292 @default.
- W1534283717 hasConcept C203014093 @default.
- W1534283717 hasConcept C2776999253 @default.
- W1534283717 hasConcept C2777658100 @default.
- W1534283717 hasConcept C2777701055 @default.
- W1534283717 hasConcept C2780868878 @default.
- W1534283717 hasConcept C2781230642 @default.
- W1534283717 hasConcept C2781249067 @default.
- W1534283717 hasConcept C2994587330 @default.
- W1534283717 hasConcept C502942594 @default.
- W1534283717 hasConcept C57074206 @default.
- W1534283717 hasConcept C71924100 @default.
- W1534283717 hasConcept C86803240 @default.
- W1534283717 hasConcept C8891405 @default.
- W1534283717 hasConcept C95444343 @default.
- W1534283717 hasConceptScore W1534283717C121608353 @default.
- W1534283717 hasConceptScore W1534283717C126322002 @default.
- W1534283717 hasConceptScore W1534283717C143998085 @default.
- W1534283717 hasConceptScore W1534283717C184235292 @default.
- W1534283717 hasConceptScore W1534283717C203014093 @default.
- W1534283717 hasConceptScore W1534283717C2776999253 @default.
- W1534283717 hasConceptScore W1534283717C2777658100 @default.
- W1534283717 hasConceptScore W1534283717C2777701055 @default.
- W1534283717 hasConceptScore W1534283717C2780868878 @default.
- W1534283717 hasConceptScore W1534283717C2781230642 @default.
- W1534283717 hasConceptScore W1534283717C2781249067 @default.
- W1534283717 hasConceptScore W1534283717C2994587330 @default.
- W1534283717 hasConceptScore W1534283717C502942594 @default.
- W1534283717 hasConceptScore W1534283717C57074206 @default.
- W1534283717 hasConceptScore W1534283717C71924100 @default.
- W1534283717 hasConceptScore W1534283717C86803240 @default.
- W1534283717 hasConceptScore W1534283717C8891405 @default.
- W1534283717 hasConceptScore W1534283717C95444343 @default.
- W1534283717 hasLocation W15342837171 @default.
- W1534283717 hasOpenAccess W1534283717 @default.
- W1534283717 hasPrimaryLocation W15342837171 @default.
- W1534283717 hasRelatedWork W1607072916 @default.
- W1534283717 hasRelatedWork W1986258970 @default.
- W1534283717 hasRelatedWork W1988618294 @default.
- W1534283717 hasRelatedWork W1990360486 @default.
- W1534283717 hasRelatedWork W2018816799 @default.
- W1534283717 hasRelatedWork W2116978375 @default.
- W1534283717 hasRelatedWork W2142072907 @default.
- W1534283717 hasRelatedWork W2334888562 @default.
- W1534283717 hasRelatedWork W2427873479 @default.
- W1534283717 hasRelatedWork W2492617148 @default.
- W1534283717 hasRelatedWork W2547428353 @default.
- W1534283717 hasRelatedWork W2577806830 @default.
- W1534283717 hasRelatedWork W2607504171 @default.
- W1534283717 hasRelatedWork W2740553855 @default.
- W1534283717 hasRelatedWork W2793701502 @default.
- W1534283717 hasRelatedWork W2894347564 @default.
- W1534283717 hasRelatedWork W2943973337 @default.
- W1534283717 hasRelatedWork W2948884915 @default.
- W1534283717 hasRelatedWork W3007855435 @default.
- W1534283717 hasRelatedWork W3117906013 @default.
- W1534283717 isParatext "false" @default.
- W1534283717 isRetracted "false" @default.
- W1534283717 magId "1534283717" @default.
- W1534283717 workType "article" @default.