Matches in SemOpenAlex for { <https://semopenalex.org/work/W1534429891> ?p ?o ?g. }
Showing items 1 to 54 of
54
with 100 items per page.
- W1534429891 endingPage "247" @default.
- W1534429891 startingPage "240" @default.
- W1534429891 abstract "Human papillomavirus (HPV) specifically infect stratified epithelial cells, causing benign and malignant neoplasia. Several elements directing this virus' genetic expression are present in a non-coding region called LCR. HPV infection starts in the basal cells of stratified epithelia, where a particular combination of cellular factors interacting with the LCR starts the transcription of the viral E6 and E7 oncogenes. The E6 and E7 genes alter the cell cycle because they interact and inactivate tumor suppressor proteins: E6 binds and degrades protein p53 and E7 associates with p105RB. E1 and E2 are the next synthesized proteins. E2 blocks the early transcription and permits E1 specific binding to the viral origin of replication located within the lcr, initiating the viral genome replication. Following the course of viral infection, the E2-induced E6 and E7 down-regulation releases p53 and p105RB proteins, and the differentiation process can continue. Then, a putative late promoter can activate the capsid genes L1 and L2. At this step, mature virions can be detected in the upper layers of the epithelium. Disruption in E2 gene transcription is usually associated to genital malignant neoplasia. In the absence of E2, E6 and E7 remain constitutively expressed, sustaining the immortality of the infected cell and blocking the epithelial differentiation program." @default.
- W1534429891 created "2016-06-24" @default.
- W1534429891 creator A5057978845 @default.
- W1534429891 creator A5080452404 @default.
- W1534429891 date "1995-05-10" @default.
- W1534429891 modified "2023-09-23" @default.
- W1534429891 title "Regulación genética de los papilomavirus humanos genitales" @default.
- W1534429891 hasPublicationYear "1995" @default.
- W1534429891 type Work @default.
- W1534429891 sameAs 1534429891 @default.
- W1534429891 citedByCount "4" @default.
- W1534429891 countsByYear W15344298912016 @default.
- W1534429891 crossrefType "journal-article" @default.
- W1534429891 hasAuthorship W1534429891A5057978845 @default.
- W1534429891 hasAuthorship W1534429891A5080452404 @default.
- W1534429891 hasConcept C104317684 @default.
- W1534429891 hasConcept C138885662 @default.
- W1534429891 hasConcept C140704245 @default.
- W1534429891 hasConcept C153911025 @default.
- W1534429891 hasConcept C159047783 @default.
- W1534429891 hasConcept C179185449 @default.
- W1534429891 hasConcept C179926584 @default.
- W1534429891 hasConcept C202878990 @default.
- W1534429891 hasConcept C2522874641 @default.
- W1534429891 hasConcept C41895202 @default.
- W1534429891 hasConcept C54355233 @default.
- W1534429891 hasConcept C86339819 @default.
- W1534429891 hasConcept C86803240 @default.
- W1534429891 hasConcept C94966510 @default.
- W1534429891 hasConcept C95444343 @default.
- W1534429891 hasConceptScore W1534429891C104317684 @default.
- W1534429891 hasConceptScore W1534429891C138885662 @default.
- W1534429891 hasConceptScore W1534429891C140704245 @default.
- W1534429891 hasConceptScore W1534429891C153911025 @default.
- W1534429891 hasConceptScore W1534429891C159047783 @default.
- W1534429891 hasConceptScore W1534429891C179185449 @default.
- W1534429891 hasConceptScore W1534429891C179926584 @default.
- W1534429891 hasConceptScore W1534429891C202878990 @default.
- W1534429891 hasConceptScore W1534429891C2522874641 @default.
- W1534429891 hasConceptScore W1534429891C41895202 @default.
- W1534429891 hasConceptScore W1534429891C54355233 @default.
- W1534429891 hasConceptScore W1534429891C86339819 @default.
- W1534429891 hasConceptScore W1534429891C86803240 @default.
- W1534429891 hasConceptScore W1534429891C94966510 @default.
- W1534429891 hasConceptScore W1534429891C95444343 @default.
- W1534429891 hasIssue "3" @default.
- W1534429891 hasOpenAccess W1534429891 @default.
- W1534429891 hasVolume "37" @default.
- W1534429891 isParatext "false" @default.
- W1534429891 isRetracted "false" @default.
- W1534429891 magId "1534429891" @default.
- W1534429891 workType "article" @default.