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• W1534452223 endingPage "802" @default.
• W1534452223 startingPage "795" @default.
• W1534452223 abstract "ABSTRACT Introduction : We investigated the extent to which intercellular adhesion molecule‐1 (ICAM‐1), a critical protein of the inflammatory response, is expressed in skeletal muscles of mdx mice (a murine model of Duchenne muscular dystrophy). Methods : Muscles were collected from control and mdx mice at 2‐24 weeks of age and analyzed for ICAM‐1 expression by means of Western blot and immunofluorescence. Results : Western blot revealed higher expression of ICAM‐1 in mdx compared with control muscles through 24 weeks of age. In contrast to control muscles, ICAM‐1 was expressed on the membrane of damaged, regenerating, and normal myofibers of mdx mice. CD11b+ myeloid cells also expressed ICAM‐1 in mdx muscles, and CD11b+ cells were closely associated with the membrane of myofibers expressing ICAM‐1. Conclusions : These findings support a paradigm in which ICAM‐1 and its localization to myofibers in muscles of mdx mice contributes to the dystrophic pathology. Muscle Nerve 52: 795–802, 2015" @default.
• W1534452223 created "2016-06-24" @default.
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• W1534452223 date "2015-06-03" @default.
• W1534452223 modified "2023-10-16" @default.
• W1534452223 title "Expression of intercellular adhesion molecule-1 by myofibers in<i>mdx</i>mice" @default.
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• W1534452223 doi "https://doi.org/10.1002/mus.24626" @default.
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