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• W1534608210 abstract "It is not the hyperglycemia that makes diabetes mellitus a devastating disease; it is the complications that arise from diabetes that make it such. Diabetic retinopathy (DR) is a complication that is caused by damaged small blood vessels of the eye, the capillaries, and is therefore termed a microvascular complication. Other diabetic complications that are microvascular are nephropathy (kidney disease) and neuropathy (nerve damage). On the other hand, a macrovascular complication is said to occur when large blood vessels such as arteries and veins are involved. To explain the role that diabetes plays in coronary heart disease (CHD), cerebrovascular accident (stroke), and hypertension the chapter discusses the biochemistry of the inner layer of blood vessels called the endothelium. Currently there are three different hypotheses that explain the underlying pathology of diabetic complications. They are glycation, sorbitol accumulation, and oxidative stress." @default.
• W1534608210 created "2016-06-24" @default.
• W1534608210 creator A5011644149 @default.
• W1534608210 date "2013-02-25" @default.
• W1534608210 modified "2023-10-14" @default.
• W1534608210 title "Complications of Diabetes Mellitus and their Pathophysiology" @default.
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• W1534608210 doi "https://doi.org/10.1002/9781118530665.ch8" @default.
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