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• W1534652943 startingPage "216" @default.
• W1534652943 abstract "1. The present review describes the mechanisms involved in controlling Ca2+ release from the sarcoplasmic reticulum (SR) of skeletal muscle, which ultimately regulates contraction. 2. Comparisons are made between cardiac and skeletal muscle with respect to: (i) the role of the dihydropyridine receptors (DHPR) as Ca2+ channels and voltage-sensors; (ii) the regulation of the ryanodine receptor (RyR)/Ca2+-release channels in the SR; and (iii) the importance of Ca2+-induced Ca2+ release. 3. It is shown that the key differences of the skeletal muscle Ca2+-release channel (RyR1), namely the increase in its stimulation by ATP and its inhibition by Mg2+, are critical for its direct regulation by the associated DHPR and, consequently, for the fast, accurate control of skeletal muscle contraction." @default.
• W1534652943 created "2016-06-24" @default.
• W1534652943 creator A5091276733 @default.
• W1534652943 date "2000-03-11" @default.
• W1534652943 modified "2023-10-15" @default.
• W1534652943 title "Excitation-Contraction Coupling In Skeletal Muscle: Comparisons With Cardiac Muscle" @default.
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• W1534652943 doi "https://doi.org/10.1046/j.1440-1681.2000.03224.x" @default.
• W1534652943 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10744351" @default.
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