FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1534709134> ?p ?o ?g. }

• W1534709134 endingPage "2818" @default.
• W1534709134 startingPage "2809" @default.
• W1534709134 abstract "The endogenous excitotoxin, glutamate (Glu), acting at the N-methyl- aspartate (NMA) subtype of Glu receptor, is thought to play a major role in hypoxic/ischemic neuronal degeneration. In the present study, the sensitivities of the developing rat CNS to hypoxic/ischemic neuronal degeneration and to the neurotoxic action of NMA were compared at various postnatal ages. In the hypoxic/ischemic experiments, ischemia was produced by unilateral common carotid artery ligation and hypoxia by subjecting the pups to a partial vacuum. Keeping the duration of the hypobaric episode constant at 75 min for all age groups, we observed that the vulnerability of the immature brain to hypobaric/ischemic damage increased during the early neonatal period (days 2–4), reached a peak at day 6 and then diminished progressively with increasing age. In the second part of the study, NMA was microinjected unilaterally into the head of the caudate nucleus at various postnatal ages (2–80 d). In the early neonatal period (days 2– 6), injections of relatively small doses of NMA (6–15 nmol) produced a dose-dependent widespread excitotoxic reaction throughout the forebrain with peak sensitivity being observed on day 6. The cytotoxic reaction to NMA was identical in appearance and time course to that induced by hypobaric/ischemic methods. With increasing age, the excitotoxic response to a given dose of NMA decreased progressively and the lesions became more strictly confined to the injection site. Cell populations most sensitive to NMA toxicity in the 2–10 d period closely correlated with those most vulnerable to hypoxia/ischemia, and sensitivity to both types of injury reached a peak at 6 d. These findings reinforce other evidence linking an excitotoxic mechanism and the NMA subtype of Glu receptor to hypoxic/ischemic brain damage and suggest that there may be a period during development when NMA receptors are hypersensitive to excitotoxic stimulation, thus rendering the neurons possessing such receptors hypervulnerable to hypoxic/ischemic damage." @default.
• W1534709134 created "2016-06-24" @default.
• W1534709134 creator A5011324497 @default.
• W1534709134 creator A5016886186 @default.
• W1534709134 creator A5017129015 @default.
• W1534709134 creator A5057829675 @default.
• W1534709134 creator A5069821756 @default.
• W1534709134 date "1989-08-01" @default.
• W1534709134 modified "2023-10-02" @default.
• W1534709134 title "Sensitivity of the developing rat brain to hypobaric/ischemic damage parallels sensitivity to N-methyl-aspartate neurotoxicity" @default.
• W1534709134 cites W1576577565 @default.
• W1534709134 cites W1576790901 @default.
• W1534709134 cites W1896045165 @default.
• W1534709134 cites W1975143757 @default.
• W1534709134 cites W1989314580 @default.
• W1534709134 cites W1995056605 @default.
• W1534709134 cites W1996664884 @default.
• W1534709134 cites W1998305119 @default.
• W1534709134 cites W1999160850 @default.
• W1534709134 cites W2007200514 @default.
• W1534709134 cites W2007449350 @default.
• W1534709134 cites W2017171491 @default.
• W1534709134 cites W2019610055 @default.
• W1534709134 cites W2020034163 @default.
• W1534709134 cites W2021195752 @default.
• W1534709134 cites W2025540461 @default.
• W1534709134 cites W2029835882 @default.
• W1534709134 cites W2048734958 @default.
• W1534709134 cites W2055585497 @default.
• W1534709134 cites W2056539638 @default.
• W1534709134 cites W2066168019 @default.
• W1534709134 cites W2087731109 @default.
• W1534709134 cites W2088829218 @default.
• W1534709134 cites W2089775599 @default.
• W1534709134 cites W2111571310 @default.
• W1534709134 cites W2405067716 @default.
• W1534709134 cites W2418182324 @default.
• W1534709134 doi "https://doi.org/10.1523/jneurosci.09-08-02809.1989" @default.
• W1534709134 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6569702" @default.
• W1534709134 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2671294" @default.
• W1534709134 hasPublicationYear "1989" @default.
• W1534709134 type Work @default.
• W1534709134 sameAs 1534709134 @default.
• W1534709134 citedByCount "327" @default.
• W1534709134 countsByYear W15347091342012 @default.
• W1534709134 countsByYear W15347091342013 @default.
• W1534709134 countsByYear W15347091342014 @default.
• W1534709134 countsByYear W15347091342015 @default.
• W1534709134 countsByYear W15347091342016 @default.
• W1534709134 countsByYear W15347091342017 @default.
• W1534709134 countsByYear W15347091342018 @default.
• W1534709134 countsByYear W15347091342019 @default.
• W1534709134 countsByYear W15347091342020 @default.
• W1534709134 countsByYear W15347091342021 @default.
• W1534709134 countsByYear W15347091342022 @default.
• W1534709134 countsByYear W15347091342023 @default.
• W1534709134 crossrefType "journal-article" @default.
• W1534709134 hasAuthorship W1534709134A5011324497 @default.
• W1534709134 hasAuthorship W1534709134A5016886186 @default.
• W1534709134 hasAuthorship W1534709134A5017129015 @default.
• W1534709134 hasAuthorship W1534709134A5057829675 @default.
• W1534709134 hasAuthorship W1534709134A5069821756 @default.
• W1534709134 hasBestOaLocation W15347091341 @default.
• W1534709134 hasConcept C126322002 @default.
• W1534709134 hasConcept C134018914 @default.
• W1534709134 hasConcept C170493617 @default.
• W1534709134 hasConcept C178790620 @default.
• W1534709134 hasConcept C179437574 @default.
• W1534709134 hasConcept C185592680 @default.
• W1534709134 hasConcept C2779491297 @default.
• W1534709134 hasConcept C2779715522 @default.
• W1534709134 hasConcept C2781458332 @default.
• W1534709134 hasConcept C29730261 @default.
• W1534709134 hasConcept C42219234 @default.
• W1534709134 hasConcept C529278444 @default.
• W1534709134 hasConcept C540031477 @default.
• W1534709134 hasConcept C541997718 @default.
• W1534709134 hasConcept C61174792 @default.
• W1534709134 hasConcept C71924100 @default.
• W1534709134 hasConcept C7836513 @default.
• W1534709134 hasConcept C86803240 @default.
• W1534709134 hasConceptScore W1534709134C126322002 @default.
• W1534709134 hasConceptScore W1534709134C134018914 @default.
• W1534709134 hasConceptScore W1534709134C170493617 @default.
• W1534709134 hasConceptScore W1534709134C178790620 @default.
• W1534709134 hasConceptScore W1534709134C179437574 @default.
• W1534709134 hasConceptScore W1534709134C185592680 @default.
• W1534709134 hasConceptScore W1534709134C2779491297 @default.
• W1534709134 hasConceptScore W1534709134C2779715522 @default.
• W1534709134 hasConceptScore W1534709134C2781458332 @default.
• W1534709134 hasConceptScore W1534709134C29730261 @default.
• W1534709134 hasConceptScore W1534709134C42219234 @default.
• W1534709134 hasConceptScore W1534709134C529278444 @default.
• W1534709134 hasConceptScore W1534709134C540031477 @default.
• W1534709134 hasConceptScore W1534709134C541997718 @default.
• W1534709134 hasConceptScore W1534709134C61174792 @default.
• W1534709134 hasConceptScore W1534709134C71924100 @default.
• W1534709134 hasConceptScore W1534709134C7836513 @default.

• next