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- W1534741036 endingPage "160" @default.
- W1534741036 startingPage "117" @default.
- W1534741036 abstract "The nicotinic acetylcholine receptor (AChR) at the neuromuscular junction transduces a chemical signal, the neurotransmitter acetylcholine released in response to an action potential at the motor nerve terminal, into an electrical event in the muscle cell that eventually activates the contraction process. In response to acetylcholine, the AChR undergoes a conformational change in which a cation-selective channel is opened, allowing sodium ions to enter and depolarize the cell. Essential functions of the receptor during this process are the binding of acetylcholine to the AChR, the coupling of the binding event to elements of the receptor comprising the channel, the opening of the channel to allow inward passage of cations, and the mechanisms that modulate these steps. Identification of the acetylcholine-binding site on the AChR would increase understanding of the mechanism by which binding of the ligand leads to the changes in the receptor that result in opening of the channel. Localization of this site is greatly facilitated by the use of snake venom curaremimetic neurotoxins, which bind to the receptor with considerably higher affinity than acetylcholine. There is evidence that the toxin-binding site includes the acetylcholine-binding site so that use of the toxins as biological probes should permit characterization of the site on the AChR involved in the binding of acetylcholine. The use of toxins as probes along with techniques employing other ligands, peptide fragments, monoclonal antibodies, synthetic receptor peptides, and genetic engineering are yielding considerable information on the toxin-binding site. In this chapter, current information on the localization of the curaremimetic neurotoxin-binding site on the primary amino acid sequence of the nicotinic AChR is discussed." @default.
- W1534741036 created "2016-06-24" @default.
- W1534741036 creator A5014886855 @default.
- W1534741036 creator A5087476009 @default.
- W1534741036 date "1988-01-01" @default.
- W1534741036 modified "2023-09-25" @default.
- W1534741036 title "Neurotoxin-Binding Site on The Acetylcholine Receptor" @default.
- W1534741036 cites W1213928540 @default.
- W1534741036 cites W137367789 @default.
- W1534741036 cites W137537019 @default.
- W1534741036 cites W1429190862 @default.
- W1534741036 cites W1481524180 @default.
- W1534741036 cites W1491063837 @default.
- W1534741036 cites W1494725790 @default.
- W1534741036 cites W1497600316 @default.
- W1534741036 cites W1503596186 @default.
- W1534741036 cites W1504043768 @default.
- W1534741036 cites W1506578135 @default.
- W1534741036 cites W1522291368 @default.
- W1534741036 cites W1529934127 @default.
- W1534741036 cites W1536136747 @default.
- W1534741036 cites W1539258258 @default.
- W1534741036 cites W1549306478 @default.
- W1534741036 cites W1552954693 @default.
- W1534741036 cites W1560768773 @default.
- W1534741036 cites W1564893509 @default.
- W1534741036 cites W1565016795 @default.
- W1534741036 cites W1568914115 @default.
- W1534741036 cites W1583990177 @default.
- W1534741036 cites W1588386708 @default.
- W1534741036 cites W1600742306 @default.
- W1534741036 cites W1615770114 @default.
- W1534741036 cites W1963871902 @default.
- W1534741036 cites W1965142345 @default.
- W1534741036 cites W1965439766 @default.
- W1534741036 cites W1966423635 @default.
- W1534741036 cites W1966634508 @default.
- W1534741036 cites W1967040054 @default.
- W1534741036 cites W1967121236 @default.
- W1534741036 cites W1967416683 @default.
- W1534741036 cites W1967453349 @default.
- W1534741036 cites W1971804776 @default.
- W1534741036 cites W1971954751 @default.
- W1534741036 cites W1972743821 @default.
- W1534741036 cites W1972961295 @default.
- W1534741036 cites W1974861780 @default.
- W1534741036 cites W1976232165 @default.
- W1534741036 cites W1977449263 @default.
- W1534741036 cites W1980512222 @default.
- W1534741036 cites W1981097868 @default.
- W1534741036 cites W1981236160 @default.
- W1534741036 cites W1984481603 @default.
- W1534741036 cites W1986865537 @default.
- W1534741036 cites W1986946637 @default.
- W1534741036 cites W1987115674 @default.
- W1534741036 cites W1988643798 @default.
- W1534741036 cites W1989779538 @default.
- W1534741036 cites W1990308142 @default.
- W1534741036 cites W1991054232 @default.
- W1534741036 cites W1991871610 @default.
- W1534741036 cites W1992516492 @default.
- W1534741036 cites W1992878995 @default.
- W1534741036 cites W1994613611 @default.
- W1534741036 cites W1994978329 @default.
- W1534741036 cites W1996304459 @default.
- W1534741036 cites W1996916918 @default.
- W1534741036 cites W1997195213 @default.
- W1534741036 cites W1997348960 @default.
- W1534741036 cites W1997803213 @default.
- W1534741036 cites W1997822414 @default.
- W1534741036 cites W2001202398 @default.
- W1534741036 cites W2001407424 @default.
- W1534741036 cites W2001855284 @default.
- W1534741036 cites W2003513113 @default.
- W1534741036 cites W2004655736 @default.
- W1534741036 cites W2005560359 @default.
- W1534741036 cites W2005982755 @default.
- W1534741036 cites W2006051310 @default.
- W1534741036 cites W2006122719 @default.
- W1534741036 cites W2006145129 @default.
- W1534741036 cites W2006292193 @default.
- W1534741036 cites W2007648438 @default.
- W1534741036 cites W2008053839 @default.
- W1534741036 cites W2008440806 @default.
- W1534741036 cites W2008500730 @default.
- W1534741036 cites W2010311047 @default.
- W1534741036 cites W2012315029 @default.
- W1534741036 cites W2013166539 @default.
- W1534741036 cites W2014760568 @default.
- W1534741036 cites W2017916064 @default.
- W1534741036 cites W2017977271 @default.
- W1534741036 cites W2018720268 @default.
- W1534741036 cites W2019433452 @default.
- W1534741036 cites W2021674040 @default.
- W1534741036 cites W2024234388 @default.
- W1534741036 cites W2027858767 @default.
- W1534741036 cites W2029531895 @default.
- W1534741036 cites W2029698716 @default.