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• W153491344 abstract "The identification of specific receptors for cardiac glycosides has been performed in cardiac muscle using intact tissue and microsomal preparations by measuring the binding characteristics of radioactive ouabain and of other cardiac glycosides. There is a large body of evidence suggesting that these specific binding sites have characteristics of functional receptors responsible for the transduction of an extracellular signal into a positive inotropic response. It is now becoming evident that these sites are related to Na+,K+-ATPase, the enzyme constitutive of the sodium pump. Therefore, digitalis receptors control not only cardiac inotropy but also the gradient of monovalent cations between the intracellular milieu and extracellular spaces. They are responsible for a wide variety of cellular functions including excitability, secretion, transmission etc.... The rate at which the sodium pump is operating is influenced largely by the relative distribution of ions across the plasma membrane. It is well established that Na activates from intracellular sites and K from extracellular ones. The purpose of this paper is to review the possible role of other factors which could be responsible for the physiological and pathophysiological control of the sodium pump. In view of the specificity of the binding sites for cardiac glycosides, we will also discuss the possible existence of endogenous specific ligands of the sodium pump." @default.
• W153491344 created "2016-06-24" @default.
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• W153491344 date "1986-01-01" @default.
• W153491344 modified "2023-10-17" @default.
• W153491344 title "Endogenous digitalis, cardiodigin and other regulators of the sodium pump" @default.
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• W153491344 doi "https://doi.org/10.1007/978-3-662-11292-2_20" @default.
• W153491344 hasPublicationYear "1986" @default.
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