FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1535034423> ?p ?o ?g. }

• W1535034423 endingPage "2238" @default.
• W1535034423 startingPage "2233" @default.
• W1535034423 abstract "Besides its well-established role in sister chromatid cohesion, cohesin has recently emerged as major player in the organization of interphase chromatin. Such important function is related to its ability to entrap two DNA segments also in cis, thereby facilitating long-range DNA looping which is crucial for transcriptional regulation, organization of replication factories and V(D)J recombination. Vertebrate somatic cells have two different versions of cohesin, containing Smc1, Smc3, Rad21/Scc1 and either SA1 or SA2, but their functional specificity has been largely ignored. We recently generated a knockout mouse model for the gene encoding SA1, and found that this protein is essential to complete embryonic development. Cohesin-SA1 mediates cohesion at telomeres, which is required for their replication. Telomere defects in SA1- deficient cells provoke chromosome segregation errors resulting in aneuploidy despite robust centromere cohesion. This aneuploidy could explain why heterozygous animals have an earlier onset of tumorigenesis. In addition, the genome-wide distribution of cohesin changes dramatically in the absence of SA1, and the complex shows reduced accumulation at promoters and CTCF sites. As a consequence, gene expression is altered, leading to downregulation of biological processes related to a developmental disorder linked to cohesin function, the Cornelia de Lange Syndrome (CdLS). These results point out a prominent role of cohesin-SA1 in transcriptional regulation, with clear implications in the etiology of CdLS." @default.
• W1535034423 created "2016-06-24" @default.
• W1535034423 creator A5028569390 @default.
• W1535034423 creator A5052689946 @default.
• W1535034423 creator A5053487646 @default.
• W1535034423 creator A5070440139 @default.
• W1535034423 creator A5079168682 @default.
• W1535034423 date "2012-06-15" @default.
• W1535034423 modified "2023-10-18" @default.
• W1535034423 title "The specific contributions of cohesin-SA1 to cohesion and gene expression" @default.
• W1535034423 cites W1794578906 @default.
• W1535034423 cites W1964368672 @default.
• W1535034423 cites W1965707365 @default.
• W1535034423 cites W1992928961 @default.
• W1535034423 cites W1994430566 @default.
• W1535034423 cites W2002921487 @default.
• W1535034423 cites W2011463791 @default.
• W1535034423 cites W2027352426 @default.
• W1535034423 cites W2028022357 @default.
• W1535034423 cites W2032492835 @default.
• W1535034423 cites W2045802318 @default.
• W1535034423 cites W2047005748 @default.
• W1535034423 cites W2053133020 @default.
• W1535034423 cites W2059171091 @default.
• W1535034423 cites W2066254965 @default.
• W1535034423 cites W2069638502 @default.
• W1535034423 cites W2078002929 @default.
• W1535034423 cites W2095944862 @default.
• W1535034423 cites W2110691960 @default.
• W1535034423 cites W2119006560 @default.
• W1535034423 cites W2119799188 @default.
• W1535034423 cites W2136202460 @default.
• W1535034423 cites W2150970239 @default.
• W1535034423 cites W2161232591 @default.
• W1535034423 cites W2170016329 @default.
• W1535034423 doi "https://doi.org/10.4161/cc.20318" @default.
• W1535034423 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22617390" @default.
• W1535034423 hasPublicationYear "2012" @default.
• W1535034423 type Work @default.
• W1535034423 sameAs 1535034423 @default.
• W1535034423 citedByCount "20" @default.
• W1535034423 countsByYear W15350344232012 @default.
• W1535034423 countsByYear W15350344232013 @default.
• W1535034423 countsByYear W15350344232014 @default.
• W1535034423 countsByYear W15350344232015 @default.
• W1535034423 countsByYear W15350344232016 @default.
• W1535034423 countsByYear W15350344232017 @default.
• W1535034423 countsByYear W15350344232018 @default.
• W1535034423 countsByYear W15350344232019 @default.
• W1535034423 countsByYear W15350344232021 @default.
• W1535034423 crossrefType "journal-article" @default.
• W1535034423 hasAuthorship W1535034423A5028569390 @default.
• W1535034423 hasAuthorship W1535034423A5052689946 @default.
• W1535034423 hasAuthorship W1535034423A5053487646 @default.
• W1535034423 hasAuthorship W1535034423A5070440139 @default.
• W1535034423 hasAuthorship W1535034423A5079168682 @default.
• W1535034423 hasConcept C104317684 @default.
• W1535034423 hasConcept C111936080 @default.
• W1535034423 hasConcept C115821613 @default.
• W1535034423 hasConcept C150194340 @default.
• W1535034423 hasConcept C152369539 @default.
• W1535034423 hasConcept C2778107874 @default.
• W1535034423 hasConcept C2778354886 @default.
• W1535034423 hasConcept C2778512757 @default.
• W1535034423 hasConcept C2778760011 @default.
• W1535034423 hasConcept C30481170 @default.
• W1535034423 hasConcept C54355233 @default.
• W1535034423 hasConcept C83640560 @default.
• W1535034423 hasConcept C86803240 @default.
• W1535034423 hasConcept C95444343 @default.
• W1535034423 hasConceptScore W1535034423C104317684 @default.
• W1535034423 hasConceptScore W1535034423C111936080 @default.
• W1535034423 hasConceptScore W1535034423C115821613 @default.
• W1535034423 hasConceptScore W1535034423C150194340 @default.
• W1535034423 hasConceptScore W1535034423C152369539 @default.
• W1535034423 hasConceptScore W1535034423C2778107874 @default.
• W1535034423 hasConceptScore W1535034423C2778354886 @default.
• W1535034423 hasConceptScore W1535034423C2778512757 @default.
• W1535034423 hasConceptScore W1535034423C2778760011 @default.
• W1535034423 hasConceptScore W1535034423C30481170 @default.
• W1535034423 hasConceptScore W1535034423C54355233 @default.
• W1535034423 hasConceptScore W1535034423C83640560 @default.
• W1535034423 hasConceptScore W1535034423C86803240 @default.
• W1535034423 hasConceptScore W1535034423C95444343 @default.
• W1535034423 hasIssue "12" @default.
• W1535034423 hasLocation W15350344231 @default.
• W1535034423 hasLocation W15350344232 @default.
• W1535034423 hasOpenAccess W1535034423 @default.
• W1535034423 hasPrimaryLocation W15350344231 @default.
• W1535034423 hasRelatedWork W1535034423 @default.
• W1535034423 hasRelatedWork W2143053537 @default.
• W1535034423 hasRelatedWork W2157131586 @default.
• W1535034423 hasRelatedWork W2791426457 @default.
• W1535034423 hasRelatedWork W2915953356 @default.
• W1535034423 hasRelatedWork W2949672039 @default.
• W1535034423 hasRelatedWork W3015504424 @default.
• W1535034423 hasRelatedWork W3194250951 @default.
• W1535034423 hasRelatedWork W4296552601 @default.

• next