Matches in SemOpenAlex for { <https://semopenalex.org/work/W1535122755> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W1535122755 abstract "Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CAProtein biomarkers can be key indicators for evaluating the presence or progression of a human disease or therapeutic response to treatment. We recently carried out a biomarker screening in hepatocellular carcinoma (HCC) using our antibody array platform. Using 25 pairs of HCC and adjacent control tissue samples, the expression levels of 274 proteins including growth factors, inflammation factors, angiogenesis, apoptosis factors and adhesion molecules, were examined using an antibody arrays. A panel of proteins demonstrating significant differences in expression levels between HCC and adjacent control samples was identified by significance analysis of microarrays (SAM) and Wilcoxon signed-rank test, combined with fold-change determination. Additionally, proteomic analysis algorithms were used to capture GO annotations and to construct signaling pathways and protein-protein interaction networks for these proteins. Proteins selected through these comprehensive analyses were designated as potential biomarkers and were well able to distinguish hepatocellular carcinoma tissue samples from paired, adjacent controls with cluster tools. The expression levels of several proteins were further evaluated by enzyme-linked immunosorbent assay (ELISA). Finally, we performed follow-up verification studies on selected proteins (Nidogen-1 and CEACAM-1) for detection of HCC in 164 pairs of serum samples from HCC patients and normal subjects with reverse phase protein array (RPPA). Our work reveals promising protein biomarkers for detection of HCC.Citation Format: Shuhong Luo, Ruochun Huang, Zhongsheng Wang, Yun-Ru Chen, Jinfei Lin, Ruo-Pan Huang. Quantitative screening of protein biomarkers of hepatocellular carcinoma by antibody array. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 2495. doi:10.1158/1538-7445.AM2014-2495" @default.
- W1535122755 created "2016-06-24" @default.
- W1535122755 creator A5011216400 @default.
- W1535122755 creator A5019213324 @default.
- W1535122755 creator A5049999064 @default.
- W1535122755 creator A5052290585 @default.
- W1535122755 creator A5075480500 @default.
- W1535122755 creator A5077630778 @default.
- W1535122755 date "2014-09-30" @default.
- W1535122755 modified "2023-09-26" @default.
- W1535122755 title "Abstract 2495: Quantitative screening of protein biomarkers of hepatocellular carcinoma by antibody array" @default.
- W1535122755 doi "https://doi.org/10.1158/1538-7445.am2014-2495" @default.
- W1535122755 hasPublicationYear "2014" @default.
- W1535122755 type Work @default.
- W1535122755 sameAs 1535122755 @default.
- W1535122755 citedByCount "0" @default.
- W1535122755 crossrefType "proceedings-article" @default.
- W1535122755 hasAuthorship W1535122755A5011216400 @default.
- W1535122755 hasAuthorship W1535122755A5019213324 @default.
- W1535122755 hasAuthorship W1535122755A5049999064 @default.
- W1535122755 hasAuthorship W1535122755A5052290585 @default.
- W1535122755 hasAuthorship W1535122755A5075480500 @default.
- W1535122755 hasAuthorship W1535122755A5077630778 @default.
- W1535122755 hasConcept C104317684 @default.
- W1535122755 hasConcept C121608353 @default.
- W1535122755 hasConcept C124535831 @default.
- W1535122755 hasConcept C126322002 @default.
- W1535122755 hasConcept C150194340 @default.
- W1535122755 hasConcept C159654299 @default.
- W1535122755 hasConcept C171196145 @default.
- W1535122755 hasConcept C195814341 @default.
- W1535122755 hasConcept C203014093 @default.
- W1535122755 hasConcept C2778019345 @default.
- W1535122755 hasConcept C2780394083 @default.
- W1535122755 hasConcept C2781197716 @default.
- W1535122755 hasConcept C46111723 @default.
- W1535122755 hasConcept C502942594 @default.
- W1535122755 hasConcept C55493867 @default.
- W1535122755 hasConcept C70721500 @default.
- W1535122755 hasConcept C71924100 @default.
- W1535122755 hasConcept C80311884 @default.
- W1535122755 hasConcept C86803240 @default.
- W1535122755 hasConcept C95371953 @default.
- W1535122755 hasConceptScore W1535122755C104317684 @default.
- W1535122755 hasConceptScore W1535122755C121608353 @default.
- W1535122755 hasConceptScore W1535122755C124535831 @default.
- W1535122755 hasConceptScore W1535122755C126322002 @default.
- W1535122755 hasConceptScore W1535122755C150194340 @default.
- W1535122755 hasConceptScore W1535122755C159654299 @default.
- W1535122755 hasConceptScore W1535122755C171196145 @default.
- W1535122755 hasConceptScore W1535122755C195814341 @default.
- W1535122755 hasConceptScore W1535122755C203014093 @default.
- W1535122755 hasConceptScore W1535122755C2778019345 @default.
- W1535122755 hasConceptScore W1535122755C2780394083 @default.
- W1535122755 hasConceptScore W1535122755C2781197716 @default.
- W1535122755 hasConceptScore W1535122755C46111723 @default.
- W1535122755 hasConceptScore W1535122755C502942594 @default.
- W1535122755 hasConceptScore W1535122755C55493867 @default.
- W1535122755 hasConceptScore W1535122755C70721500 @default.
- W1535122755 hasConceptScore W1535122755C71924100 @default.
- W1535122755 hasConceptScore W1535122755C80311884 @default.
- W1535122755 hasConceptScore W1535122755C86803240 @default.
- W1535122755 hasConceptScore W1535122755C95371953 @default.
- W1535122755 hasLocation W15351227551 @default.
- W1535122755 hasOpenAccess W1535122755 @default.
- W1535122755 hasPrimaryLocation W15351227551 @default.
- W1535122755 hasRelatedWork W1966556779 @default.
- W1535122755 hasRelatedWork W1977653027 @default.
- W1535122755 hasRelatedWork W1997352005 @default.
- W1535122755 hasRelatedWork W1998046993 @default.
- W1535122755 hasRelatedWork W2007469452 @default.
- W1535122755 hasRelatedWork W2018823546 @default.
- W1535122755 hasRelatedWork W2073560670 @default.
- W1535122755 hasRelatedWork W2077139546 @default.
- W1535122755 hasRelatedWork W2122595149 @default.
- W1535122755 hasRelatedWork W2128424878 @default.
- W1535122755 hasRelatedWork W2269175947 @default.
- W1535122755 hasRelatedWork W2290243397 @default.
- W1535122755 hasRelatedWork W2416134895 @default.
- W1535122755 hasRelatedWork W2522010589 @default.
- W1535122755 hasRelatedWork W2609360888 @default.
- W1535122755 hasRelatedWork W2741160767 @default.
- W1535122755 hasRelatedWork W2790169109 @default.
- W1535122755 hasRelatedWork W3034663877 @default.
- W1535122755 hasRelatedWork W3197338664 @default.
- W1535122755 hasRelatedWork W3205212328 @default.
- W1535122755 isParatext "false" @default.
- W1535122755 isRetracted "false" @default.
- W1535122755 magId "1535122755" @default.
- W1535122755 workType "article" @default.