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• W1535131498 abstract "Pathogen inactivation (PI) technologies for platelets aim to improve transfusion safety by preventing the replication of contaminating pathogens. However, as a consequence of treatment, aspects of the platelet storage lesion are amplified. Mirasol treatment also affects platelet signal transduction and apoptotic protein expression. The aim of this study was to examine the effect of Mirasol treatment on the generation of reactive oxygen species (ROS) and subsequent oxidative stress.Pooled platelet concentrates were prepared in platelet-additive solution (70% SSP+ / 30% plasma). ABO-matched platelets were pooled and split, and treated with the Mirasol system (TerumoBCT) or left untreated as a control. Platelet samples were tested on day 1, 5, and 7 post-collection.Mirasol-treated platelets had increased formation of ROS by day 5 of storage. Oxidative damage, in the form of protein carbonylation, was higher in Mirasol-treated platelets, whilst no effect on nitrotyrosine formation or lipid peroxidation was detected. The NF-κB signaling pathway was also activated in Mirasol-treated platelets, with increased expression and phosphorylation of NF-κB p65 and IκBα.These data demonstrate that Mirasol-treated platelets produce more ROS and display protein alterations consistent with oxidative damage." @default.
• W1535131498 created "2016-06-24" @default.
• W1535131498 creator A5049621887 @default.
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• W1535131498 date "2015-01-01" @default.
• W1535131498 modified "2023-10-16" @default.
• W1535131498 title "Treatment of Platelet Concentrates with the Mirasol Pathogen Inactivation System Modulates Platelet Oxidative Stress and NF-&#954;B Activation" @default.
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• W1535131498 doi "https://doi.org/10.1159/000403245" @default.
• W1535131498 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4483294" @default.
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• W1535131498 hasPublicationYear "2015" @default.
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