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- W153513436 abstract "MicroRNAs (miRNAs) are 21–23-nucleotide non-protein-coding RNA molecules that act as negative regulators of gene expression, modulating the stability and/or the translational efficiency of target messenger RNAs. This chapter describes miRNA regulation and function in tissue response to acute ischemia, focusing on miRNAs role in acute myocardial infarction. The role played by specific miRNAs in the regulation of apoptosis, fibrosis, regeneration, and myocardial arrhythmias is illustrated. Examples of the miRNA involvement in noncardiac ischemia are also included. The identification of specific miRNAs as key regulators of the response to ischemia has opened new clinical avenues. miRNAs may constitute excellent noninvasive disease biomarkers. Furthermore, innovative strategies targeting miRNAs, aimed at reducing the levels of pathogenic or aberrantly expressed miRNAs or to elevate the levels of miRNAs with beneficial functions, have been developed and could be applied in the treatment of ischemic diseases. The efficacy of these strategies is confirmed by two paradigmatic reports in which miRNAs have been targeted to improve cardiac function in preclinical models of myocardial infarction. Specifically, miR-210 upregulation and miR-15 inhibition can both protect against cardiac injury and rescue cardiac function after myocardial infarction." @default.
- W153513436 created "2016-06-24" @default.
- W153513436 creator A5011791947 @default.
- W153513436 creator A5075376877 @default.
- W153513436 date "2013-01-01" @default.
- W153513436 modified "2023-09-23" @default.
- W153513436 title "MicroRNAs and Tissue Response to Acute Ischemia" @default.
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- W153513436 doi "https://doi.org/10.1007/978-88-470-5379-3_7" @default.
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