Matches in SemOpenAlex for { <https://semopenalex.org/work/W1535134773> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W1535134773 endingPage "1201" @default.
- W1535134773 startingPage "1195" @default.
- W1535134773 abstract "Object Traumatic brain injury (TBI) induces significant neurological damage, including deficits in learning and memory, which contribute to a poor clinical prognosis. Treatment options to limit cognitive decline and promote neurological recovery are lacking, in part due to a poor understanding of the secondary or delayed processes that contribute to brain injury. In the present study, the authors characterized the temporal and spatial changes in the expression of postsynaptic density protein-95 (PSD-95), a key scaffolding protein implicated in excitatory synaptic signaling, after controlled cortical impacts in mice. Neurological injury, as assessed by the open-field activity test and the novel object recognition test, was compared with changes in PSD-95 expression. Methods Adult male CD-1 mice were subjected to controlled cortical impacts to simulate moderate TBI in humans. The spatial and temporal expression of PSD-95 was analyzed in the cerebral cortex and hippocampus at various time points following injury and sham operations. Neurological assessments were performed to compare changes in PSD-95 with cognitive deficits. Results A significant decrease in PSD-95 expression was observed in the ipsilateral hippocampus beginning on Day 7 postinjury. The loss of PSD-95 corresponded with a concomitant reduction in immunoreactivity for NeuN (neuronal nuclei), a neuron-specific marker. Aside from the contused cortex, a significant loss of PSD-95 immunoreactivity was not observed in the cerebral cortex. The delayed loss of hippocampal PSD-95 directly correlated with the onset of behavioral deficits, suggesting a possible causative role for PSD-95 in behavioral abnormalities following head trauma. Conclusions A delayed loss of hippocampal synapses was observed following head trauma in mice. These data may suggest a cellular mechanism to explain the delayed learning and memory deficits in humans after TBI and provide a potential framework for further testing to implicate PSD-95 as a clinically relevant therapeutic target." @default.
- W1535134773 created "2016-06-24" @default.
- W1535134773 creator A5002486084 @default.
- W1535134773 creator A5003140566 @default.
- W1535134773 creator A5022034289 @default.
- W1535134773 creator A5030629405 @default.
- W1535134773 creator A5060236699 @default.
- W1535134773 date "2010-12-01" @default.
- W1535134773 modified "2023-10-16" @default.
- W1535134773 title "Delayed reduction in hippocampal postsynaptic density protein-95 expression temporally correlates with cognitive dysfunction following controlled cortical impact in mice" @default.
- W1535134773 cites W1588780906 @default.
- W1535134773 doi "https://doi.org/10.3171/2010.3.jns091212" @default.
- W1535134773 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3155981" @default.
- W1535134773 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20397893" @default.
- W1535134773 hasPublicationYear "2010" @default.
- W1535134773 type Work @default.
- W1535134773 sameAs 1535134773 @default.
- W1535134773 citedByCount "79" @default.
- W1535134773 countsByYear W15351347732012 @default.
- W1535134773 countsByYear W15351347732013 @default.
- W1535134773 countsByYear W15351347732014 @default.
- W1535134773 countsByYear W15351347732015 @default.
- W1535134773 countsByYear W15351347732016 @default.
- W1535134773 countsByYear W15351347732017 @default.
- W1535134773 countsByYear W15351347732018 @default.
- W1535134773 countsByYear W15351347732019 @default.
- W1535134773 countsByYear W15351347732020 @default.
- W1535134773 countsByYear W15351347732021 @default.
- W1535134773 countsByYear W15351347732022 @default.
- W1535134773 countsByYear W15351347732023 @default.
- W1535134773 crossrefType "journal-article" @default.
- W1535134773 hasAuthorship W1535134773A5002486084 @default.
- W1535134773 hasAuthorship W1535134773A5003140566 @default.
- W1535134773 hasAuthorship W1535134773A5022034289 @default.
- W1535134773 hasAuthorship W1535134773A5030629405 @default.
- W1535134773 hasAuthorship W1535134773A5060236699 @default.
- W1535134773 hasBestOaLocation W15351347731 @default.
- W1535134773 hasConcept C112592302 @default.
- W1535134773 hasConcept C118552586 @default.
- W1535134773 hasConcept C126322002 @default.
- W1535134773 hasConcept C148762608 @default.
- W1535134773 hasConcept C15744967 @default.
- W1535134773 hasConcept C169760540 @default.
- W1535134773 hasConcept C170493617 @default.
- W1535134773 hasConcept C17077164 @default.
- W1535134773 hasConcept C187541742 @default.
- W1535134773 hasConcept C197341189 @default.
- W1535134773 hasConcept C204232928 @default.
- W1535134773 hasConcept C2781017439 @default.
- W1535134773 hasConcept C2781041448 @default.
- W1535134773 hasConcept C2781100881 @default.
- W1535134773 hasConcept C2781161787 @default.
- W1535134773 hasConcept C2781458332 @default.
- W1535134773 hasConcept C71924100 @default.
- W1535134773 hasConceptScore W1535134773C112592302 @default.
- W1535134773 hasConceptScore W1535134773C118552586 @default.
- W1535134773 hasConceptScore W1535134773C126322002 @default.
- W1535134773 hasConceptScore W1535134773C148762608 @default.
- W1535134773 hasConceptScore W1535134773C15744967 @default.
- W1535134773 hasConceptScore W1535134773C169760540 @default.
- W1535134773 hasConceptScore W1535134773C170493617 @default.
- W1535134773 hasConceptScore W1535134773C17077164 @default.
- W1535134773 hasConceptScore W1535134773C187541742 @default.
- W1535134773 hasConceptScore W1535134773C197341189 @default.
- W1535134773 hasConceptScore W1535134773C204232928 @default.
- W1535134773 hasConceptScore W1535134773C2781017439 @default.
- W1535134773 hasConceptScore W1535134773C2781041448 @default.
- W1535134773 hasConceptScore W1535134773C2781100881 @default.
- W1535134773 hasConceptScore W1535134773C2781161787 @default.
- W1535134773 hasConceptScore W1535134773C2781458332 @default.
- W1535134773 hasConceptScore W1535134773C71924100 @default.
- W1535134773 hasIssue "6" @default.
- W1535134773 hasLocation W15351347731 @default.
- W1535134773 hasLocation W15351347732 @default.
- W1535134773 hasLocation W15351347733 @default.
- W1535134773 hasLocation W15351347734 @default.
- W1535134773 hasOpenAccess W1535134773 @default.
- W1535134773 hasPrimaryLocation W15351347731 @default.
- W1535134773 hasRelatedWork W1994952783 @default.
- W1535134773 hasRelatedWork W2010108080 @default.
- W1535134773 hasRelatedWork W2056145172 @default.
- W1535134773 hasRelatedWork W2069362932 @default.
- W1535134773 hasRelatedWork W2089862144 @default.
- W1535134773 hasRelatedWork W2138730144 @default.
- W1535134773 hasRelatedWork W2762958751 @default.
- W1535134773 hasRelatedWork W3164321664 @default.
- W1535134773 hasRelatedWork W4206637469 @default.
- W1535134773 hasRelatedWork W4285127779 @default.
- W1535134773 hasVolume "113" @default.
- W1535134773 isParatext "false" @default.
- W1535134773 isRetracted "false" @default.
- W1535134773 magId "1535134773" @default.
- W1535134773 workType "article" @default.