FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1535142703> ?p ?o ?g. }

• W1535142703 endingPage "13" @default.
• W1535142703 startingPage "1" @default.
• W1535142703 abstract "Coronary artery stenting or angioplasty procedures frequently result in long-term endothelial dysfunction or loss and complications including arterial thrombosis and myocardial infarction. Stem cell-based therapies have been proposed to support endothelial regeneration. Mesenchymal stem cells (MSCs) differentiate into endothelial cells (ECs) in the presence of VEGF-A in vitro. Application of VEGF-A and MSC-derived ECs at the interventional site is a complex clinical challenge. In this study, we examined the effect of atherogenic cytokines (IL-6, TNFα, and Ang II) on EC differentiation and function. MSCs (CD44(+), CD73(+), CD90(+), CD14(-), and CD45(-)) were isolated from the bone marrow of Yucatan microswine. Naïve MSCs cultured in differentiation media containing VEGF-A (50 ng/mL) demonstrated increased expression of EC-specific markers (vWF, PECAM-1, and VE-cadherin), VEGFR-2 and Sox18, and enhanced endothelial tube formation. IL-6 or TNFα caused a dose-dependent attenuation of EC marker expression in VEGF-A-stimulated MSCs. In contrast, Ang II enhanced EC marker expression in VEGF-A-stimulated MSCs. Addition of Ang II to VEGF-A and IL-6 or TNFα was sufficient to rescue the EC phenotype. Thus, Ang II promotes but IL-6 and TNFα inhibit VEGF-A-induced differentiation of MSCs into ECs. These findings have important clinical implications for therapies intended to increase cardiac vascularity and reendothelialize coronary arteries following intervention." @default.
• W1535142703 created "2016-06-24" @default.
• W1535142703 creator A5001855337 @default.
• W1535142703 creator A5007467595 @default.
• W1535142703 creator A5019762392 @default.
• W1535142703 date "2015-01-01" @default.
• W1535142703 modified "2023-10-18" @default.
• W1535142703 title "Atherogenic Cytokines Regulate VEGF-A-Induced Differentiation of Bone Marrow-Derived Mesenchymal Stem Cells into Endothelial Cells" @default.
• W1535142703 cites W1553679206 @default.
• W1535142703 cites W1970709580 @default.
• W1535142703 cites W1971678928 @default.
• W1535142703 cites W1997002994 @default.
• W1535142703 cites W2004172521 @default.
• W1535142703 cites W2010094572 @default.
• W1535142703 cites W2013810392 @default.
• W1535142703 cites W2014077602 @default.
• W1535142703 cites W2017325045 @default.
• W1535142703 cites W2038250406 @default.
• W1535142703 cites W2041825870 @default.
• W1535142703 cites W2047972161 @default.
• W1535142703 cites W2050856345 @default.
• W1535142703 cites W2057896668 @default.
• W1535142703 cites W2075528363 @default.
• W1535142703 cites W2083736312 @default.
• W1535142703 cites W2086668249 @default.
• W1535142703 cites W2104139750 @default.
• W1535142703 cites W2105857956 @default.
• W1535142703 cites W2107644323 @default.
• W1535142703 cites W2121822802 @default.
• W1535142703 cites W2132697533 @default.
• W1535142703 cites W2141046053 @default.
• W1535142703 cites W2144301584 @default.
• W1535142703 cites W2145121923 @default.
• W1535142703 cites W2145291679 @default.
• W1535142703 cites W2158135412 @default.
• W1535142703 cites W2162412444 @default.
• W1535142703 cites W2170611396 @default.
• W1535142703 cites W2171445986 @default.
• W1535142703 cites W2171706522 @default.
• W1535142703 cites W33955680 @default.
• W1535142703 cites W4292022394 @default.
• W1535142703 cites W4211200033 @default.
• W1535142703 doi "https://doi.org/10.1155/2015/498328" @default.
• W1535142703 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4464597" @default.
• W1535142703 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26106428" @default.
• W1535142703 hasPublicationYear "2015" @default.
• W1535142703 type Work @default.
• W1535142703 sameAs 1535142703 @default.
• W1535142703 citedByCount "21" @default.
• W1535142703 countsByYear W15351427032016 @default.
• W1535142703 countsByYear W15351427032017 @default.
• W1535142703 countsByYear W15351427032018 @default.
• W1535142703 countsByYear W15351427032019 @default.
• W1535142703 countsByYear W15351427032020 @default.
• W1535142703 countsByYear W15351427032021 @default.
• W1535142703 countsByYear W15351427032022 @default.
• W1535142703 countsByYear W15351427032023 @default.
• W1535142703 crossrefType "journal-article" @default.
• W1535142703 hasAuthorship W1535142703A5001855337 @default.
• W1535142703 hasAuthorship W1535142703A5007467595 @default.
• W1535142703 hasAuthorship W1535142703A5019762392 @default.
• W1535142703 hasBestOaLocation W15351427031 @default.
• W1535142703 hasConcept C10205521 @default.
• W1535142703 hasConcept C116716535 @default.
• W1535142703 hasConcept C142724271 @default.
• W1535142703 hasConcept C198826908 @default.
• W1535142703 hasConcept C202751555 @default.
• W1535142703 hasConcept C203014093 @default.
• W1535142703 hasConcept C2780007613 @default.
• W1535142703 hasConcept C2780932548 @default.
• W1535142703 hasConcept C28328180 @default.
• W1535142703 hasConcept C502942594 @default.
• W1535142703 hasConcept C55493867 @default.
• W1535142703 hasConcept C71924100 @default.
• W1535142703 hasConcept C86803240 @default.
• W1535142703 hasConcept C95444343 @default.
• W1535142703 hasConceptScore W1535142703C10205521 @default.
• W1535142703 hasConceptScore W1535142703C116716535 @default.
• W1535142703 hasConceptScore W1535142703C142724271 @default.
• W1535142703 hasConceptScore W1535142703C198826908 @default.
• W1535142703 hasConceptScore W1535142703C202751555 @default.
• W1535142703 hasConceptScore W1535142703C203014093 @default.
• W1535142703 hasConceptScore W1535142703C2780007613 @default.
• W1535142703 hasConceptScore W1535142703C2780932548 @default.
• W1535142703 hasConceptScore W1535142703C28328180 @default.
• W1535142703 hasConceptScore W1535142703C502942594 @default.
• W1535142703 hasConceptScore W1535142703C55493867 @default.
• W1535142703 hasConceptScore W1535142703C71924100 @default.
• W1535142703 hasConceptScore W1535142703C86803240 @default.
• W1535142703 hasConceptScore W1535142703C95444343 @default.
• W1535142703 hasFunder F4320332161 @default.
• W1535142703 hasLocation W15351427031 @default.
• W1535142703 hasLocation W15351427032 @default.
• W1535142703 hasLocation W15351427033 @default.
• W1535142703 hasLocation W15351427034 @default.
• W1535142703 hasLocation W15351427035 @default.
• W1535142703 hasOpenAccess W1535142703 @default.
• W1535142703 hasPrimaryLocation W15351427031 @default.

• next