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- W1535167183 abstract "Publisher Summary This chapter discusses that the glutamate antagonist riluzole (RLZ) interferes with the capability of the motor cortex to react with excitability changes to transcranial direct current stimulation (tDCS) in a manner similar to the previously tested NMDA receptor blocker DMO. DMO has been shown to prevent hyperexcitability after anodal as well as hypoexcitability after cathodal tDCS. RLZ is assumed to influence different pre- and postsynaptic processes of glutamate transmission. Different non-glutamatergic actions of RLZ and DMO could be responsible for the dissimilar interference of these drugs with the tDCS after-effects. In addition to the blockade of NMDA receptors, DMO causes a partial inhibition of voltage-dependent calcium and sodium channels. To gain insight into the functionality of tDCS by unravelling receptor and channel effects on the basis of pharmacological interactions with tDCS-induced after-effects has been the major objective of hitherto performed and ongoing pharmacological tDCS studies." @default.
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- W1535167183 date "2003-01-01" @default.
- W1535167183 modified "2023-09-27" @default.
- W1535167183 title "Chapter 29 Pharmacology of transcranial direct current stimulation: missing effect of riluzole" @default.
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- W1535167183 doi "https://doi.org/10.1016/s1567-424x(09)70232-6" @default.
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