Matches in SemOpenAlex for { <https://semopenalex.org/work/W1535188277> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W1535188277 endingPage "60" @default.
- W1535188277 startingPage "56" @default.
- W1535188277 abstract "In contrast to intrauterine rubella infection, the relationship between timing of maternal cytomegalovirus (CMV) infection and fetal outcome has not been clearly defined. In order to investigate this relationship, a guinea pig model was utilized to assess the fetal consequences of maternal CMV infection during the first, second, or third trimester of pregnancy. Congenital infection occurred in 24 of 35 newborn guinea pigs (69%) delivered to mothers infected during the third trimester, with localization of virus to salivary gland in 17 of the 24 infected newborn guinea pigs. In contrast, only one of 28 (5%) progeny sacrificed following first-trimester maternal infection was congenitally infected (p < 0.01). Second-trimester maternal infection was associated with an intermediate risk of intrauterine infection with transmission of virus to 17 of 54 progeny (33%) (p < 0.01). Eight of the 10 fetuses delivered after second-trimester infection had virus in multiple organs including the brain. These data suggest that timing of maternal CMV infection is an important variable affecting fetal outcome, with increased risk of intrauterine infection when maternal infection occurs late in pregnancy. However, if fetal infection occurs earlier in pregnancy, it appears to present a greater threat to the fetus, with the potential for dissemination of virus in multiple fetal tissues, including the brain." @default.
- W1535188277 created "2016-06-24" @default.
- W1535188277 creator A5077394565 @default.
- W1535188277 creator A5084889162 @default.
- W1535188277 date "1983-01-01" @default.
- W1535188277 modified "2023-10-11" @default.
- W1535188277 title "Experimental primary cytomegalovirus infection in pregnancy: Timing and fetal outcome" @default.
- W1535188277 cites W1934560160 @default.
- W1535188277 cites W1973104855 @default.
- W1535188277 cites W2032548199 @default.
- W1535188277 cites W2045091800 @default.
- W1535188277 cites W2059384046 @default.
- W1535188277 cites W2075513582 @default.
- W1535188277 cites W2081095625 @default.
- W1535188277 cites W2147055819 @default.
- W1535188277 cites W2325839841 @default.
- W1535188277 cites W2334988826 @default.
- W1535188277 cites W2416609421 @default.
- W1535188277 cites W2417395553 @default.
- W1535188277 cites W4205352081 @default.
- W1535188277 doi "https://doi.org/10.1016/0002-9378(83)90339-3" @default.
- W1535188277 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6295164" @default.
- W1535188277 hasPublicationYear "1983" @default.
- W1535188277 type Work @default.
- W1535188277 sameAs 1535188277 @default.
- W1535188277 citedByCount "31" @default.
- W1535188277 countsByYear W15351882772015 @default.
- W1535188277 countsByYear W15351882772021 @default.
- W1535188277 crossrefType "journal-article" @default.
- W1535188277 hasAuthorship W1535188277A5077394565 @default.
- W1535188277 hasAuthorship W1535188277A5084889162 @default.
- W1535188277 hasConcept C131872663 @default.
- W1535188277 hasConcept C172680121 @default.
- W1535188277 hasConcept C203014093 @default.
- W1535188277 hasConcept C22070199 @default.
- W1535188277 hasConcept C2522874641 @default.
- W1535188277 hasConcept C2776409557 @default.
- W1535188277 hasConcept C2776438120 @default.
- W1535188277 hasConcept C2777732132 @default.
- W1535188277 hasConcept C2778097271 @default.
- W1535188277 hasConcept C2778814567 @default.
- W1535188277 hasConcept C2779234561 @default.
- W1535188277 hasConcept C2780727368 @default.
- W1535188277 hasConcept C42407357 @default.
- W1535188277 hasConcept C54355233 @default.
- W1535188277 hasConcept C71924100 @default.
- W1535188277 hasConcept C86803240 @default.
- W1535188277 hasConceptScore W1535188277C131872663 @default.
- W1535188277 hasConceptScore W1535188277C172680121 @default.
- W1535188277 hasConceptScore W1535188277C203014093 @default.
- W1535188277 hasConceptScore W1535188277C22070199 @default.
- W1535188277 hasConceptScore W1535188277C2522874641 @default.
- W1535188277 hasConceptScore W1535188277C2776409557 @default.
- W1535188277 hasConceptScore W1535188277C2776438120 @default.
- W1535188277 hasConceptScore W1535188277C2777732132 @default.
- W1535188277 hasConceptScore W1535188277C2778097271 @default.
- W1535188277 hasConceptScore W1535188277C2778814567 @default.
- W1535188277 hasConceptScore W1535188277C2779234561 @default.
- W1535188277 hasConceptScore W1535188277C2780727368 @default.
- W1535188277 hasConceptScore W1535188277C42407357 @default.
- W1535188277 hasConceptScore W1535188277C54355233 @default.
- W1535188277 hasConceptScore W1535188277C71924100 @default.
- W1535188277 hasConceptScore W1535188277C86803240 @default.
- W1535188277 hasIssue "1" @default.
- W1535188277 hasLocation W15351882771 @default.
- W1535188277 hasLocation W15351882772 @default.
- W1535188277 hasOpenAccess W1535188277 @default.
- W1535188277 hasPrimaryLocation W15351882771 @default.
- W1535188277 hasRelatedWork W1551259868 @default.
- W1535188277 hasRelatedWork W1968064539 @default.
- W1535188277 hasRelatedWork W2027584390 @default.
- W1535188277 hasRelatedWork W2048787397 @default.
- W1535188277 hasRelatedWork W2076034535 @default.
- W1535188277 hasRelatedWork W2264417332 @default.
- W1535188277 hasRelatedWork W2273003743 @default.
- W1535188277 hasRelatedWork W2282295624 @default.
- W1535188277 hasRelatedWork W2989770337 @default.
- W1535188277 hasRelatedWork W3029066628 @default.
- W1535188277 hasVolume "145" @default.
- W1535188277 isParatext "false" @default.
- W1535188277 isRetracted "false" @default.
- W1535188277 magId "1535188277" @default.
- W1535188277 workType "article" @default.